Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression. - Cobo I; Murillo-Saich J; Alishala M; Calderon S; Coras R; Hemming B; Inkum F; Rosas F; Takei R; Spann N; Prohaska TA; Alabarse PVG; et al. (Immunity, 2025)