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The LRRK2 p.L1795F variant causes Parkinson's disease in the European population.

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Title: The LRRK2 p.L1795F variant causes Parkinson's disease in the European population.
Authors: Lange LM; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany. la.lange@uni-luebeck.de.; Department of Neurology, University Hospital Schleswig-Holstein, Luebeck, Germany. la.lange@uni-luebeck.de.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. la.lange@uni-luebeck.de., Levine K; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Fox SH; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada., Marras C; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada., Ahmed N; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada., Kuznetsov N; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Vitale D; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Iwaki H; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Lohmann K; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany., Marsili L; University of Cincinnati, Cincinnati, OH, USA., Espay AJ; University of Cincinnati, Cincinnati, OH, USA., Bauer P; CENTOGENE GmbH, Rostock, Germany., Beetz C; CENTOGENE GmbH, Rostock, Germany., Martin J; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Factor SA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Higginbotham LA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Chen H; Department of Epidemiology and Biostatistics, Michigan State University, Michigan, MI, USA., Leonard H; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Nalls MA; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Mencacci NE; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Morris HR; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; UCL Movement Disorders Centre, University College London, London, UK., Singleton AB; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Klein C; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.; Department of Neurology, University Hospital Schleswig-Holstein, Luebeck, Germany., Blauwendraat C; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Fang ZH; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Zih-Hua.Fang@dzne.de.
Corporate Authors: Global Parkinson’s Genetics Program (GP2)
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Mar 25; Vol. 11 (1), pp. 58. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The LRRK2 p.L1795F variant causes Parkinson's disease in the European population.
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  Data: <searchLink fieldCode="AU" term="%22Lange+LM%22">Lange LM</searchLink>; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany. la.lange@uni-luebeck.de.; Department of Neurology, University Hospital Schleswig-Holstein, Luebeck, Germany. la.lange@uni-luebeck.de.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. la.lange@uni-luebeck.de.<br /><searchLink fieldCode="AU" term="%22Levine+K%22">Levine K</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fox+SH%22">Fox SH</searchLink>; Edmond J. 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Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kuznetsov+N%22">Kuznetsov N</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vitale+D%22">Vitale D</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Iwaki+H%22">Iwaki H</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lohmann+K%22">Lohmann K</searchLink>; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.<br /><searchLink fieldCode="AU" term="%22Marsili+L%22">Marsili L</searchLink>; University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Espay+AJ%22">Espay AJ</searchLink>; University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Bauer+P%22">Bauer P</searchLink>; CENTOGENE GmbH, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Beetz+C%22">Beetz C</searchLink>; CENTOGENE GmbH, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Martin+J%22">Martin J</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Factor+SA%22">Factor SA</searchLink>; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Higginbotham+LA%22">Higginbotham LA</searchLink>; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Epidemiology and Biostatistics, Michigan State University, Michigan, MI, USA.<br /><searchLink fieldCode="AU" term="%22Leonard+H%22">Leonard H</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nalls+MA%22">Nalls MA</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mencacci+NE%22">Mencacci NE</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Morris+HR%22">Morris HR</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; UCL Movement Disorders Centre, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Singleton+AB%22">Singleton AB</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.; Department of Neurology, University Hospital Schleswig-Holstein, Luebeck, Germany.<br /><searchLink fieldCode="AU" term="%22Blauwendraat+C%22">Blauwendraat C</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fang+ZH%22">Fang ZH</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Zih-Hua.Fang@dzne.de.
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