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Escitalopram for agitation in Alzheimer's dementia: a randomized controlled phase 3 trial.

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Title: Escitalopram for agitation in Alzheimer's dementia: a randomized controlled phase 3 trial.
Authors: Rajji TK; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. tarek.rajji@utsouthwestern.edu.; Department of Psychiatry and Toronto Dementia Research Alliance, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. tarek.rajji@utsouthwestern.edu.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. tarek.rajji@utsouthwestern.edu., Baksh SN; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Shade DM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Ismail Z; Departments of Psychiatry, Clinical Neurosciences and Community Health Sciences, Hotchkiss Brain Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada., Burhan AM; Department of Psychiatry and Toronto Dementia Research Alliance, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Ontario Shores Centre for Mental Health Sciences, Whitby, Ontario, Canada., Okhravi HR; Department of Medicine, Lawrence J. Goldrich Institute for Integrated Neuro-Health, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA., Padala PR; Central Arkansas Veterans Healthcare System and College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Rosenberg PB; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD, USA., Schneider LS; Department of Psychiatry and the Behavioral Sciences and Department of Neurology, University of Southern California Keck School of Medicine and the University of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA., Porsteinsson AP; Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Lyketsos CG; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
Corporate Authors: S-CitAD Research Group
Source: Nature medicine [Nat Med] 2025 May; Vol. 31 (5), pp. 1586-1591. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rajji+TK%22">Rajji TK</searchLink>; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. tarek.rajji@utsouthwestern.edu.; Department of Psychiatry and Toronto Dementia Research Alliance, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. tarek.rajji@utsouthwestern.edu.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. tarek.rajji@utsouthwestern.edu.<br /><searchLink fieldCode="AU" term="%22Baksh+SN%22">Baksh SN</searchLink>; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shade+DM%22">Shade DM</searchLink>; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ismail+Z%22">Ismail Z</searchLink>; Departments of Psychiatry, Clinical Neurosciences and Community Health Sciences, Hotchkiss Brain Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Burhan+AM%22">Burhan AM</searchLink>; Department of Psychiatry and Toronto Dementia Research Alliance, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Ontario Shores Centre for Mental Health Sciences, Whitby, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Okhravi+HR%22">Okhravi HR</searchLink>; Department of Medicine, Lawrence J. Goldrich Institute for Integrated Neuro-Health, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.<br /><searchLink fieldCode="AU" term="%22Padala+PR%22">Padala PR</searchLink>; Central Arkansas Veterans Healthcare System and College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Rosenberg+PB%22">Rosenberg PB</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+LS%22">Schneider LS</searchLink>; Department of Psychiatry and the Behavioral Sciences and Department of Neurology, University of Southern California Keck School of Medicine and the University of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Porsteinsson+AP%22">Porsteinsson AP</searchLink>; Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lyketsos+CG%22">Lyketsos CG</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2025 May; Vol. 31 (5), pp. 1586-1591. <i>Date of Electronic Publication: </i>2025 Mar 25.
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