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4-Hydroxycoumarin Exhibits Antinociceptive and Anti-Inflammatory Effects Through Cytokine Modulation: An Integrated In Silico and In Vivo Study.

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Title: 4-Hydroxycoumarin Exhibits Antinociceptive and Anti-Inflammatory Effects Through Cytokine Modulation: An Integrated In Silico and In Vivo Study.
Authors: da Fonsêca DV; Postgraduate Program in Biosciences, Federal University of the São Francisco Valley (UNIVASF), Pernambuco 56304-917, PE, Brazil., Rocha JS; Postgraduate Program in Biosciences, Federal University of the São Francisco Valley (UNIVASF), Pernambuco 56304-917, PE, Brazil., da Silva PR; Postgraduate Program of Dentistry (PPGO), Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.; Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.; Postgraduate Program in Natural Synthetic and Bioactive Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil., de Sá Novaes Pereira HN; Department of Medicine, Federal University of the São Francisco Valley (UNIVASF), Paulo Afonso 48605-560, BA, Brazil., Dos Santos LVN; Department of Medicine, Faculdade Estácio IDOMED, Juazeiro 48924-999, BA, Brazil., de Santana MAD; Departament of Morphology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Alves AF; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil., Pontes AHO; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil., de Souza Gomes J; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil., Felipe CFB; Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.; Postgraduate Program in Natural Synthetic and Bioactive Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil., de Sousa DP; Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil., Scotti MT; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil., Scotti L; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 19; Vol. 26 (6). Date of Electronic Publication: 2025 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 4-Hydroxycoumarin Exhibits Antinociceptive and Anti-Inflammatory Effects Through Cytokine Modulation: An Integrated In Silico and In Vivo Study.
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  Data: <searchLink fieldCode="AU" term="%22da+Fonsêca+DV%22">da Fonsêca DV</searchLink>; Postgraduate Program in Biosciences, Federal University of the São Francisco Valley (UNIVASF), Pernambuco 56304-917, PE, Brazil.<br /><searchLink fieldCode="AU" term="%22Rocha+JS%22">Rocha JS</searchLink>; Postgraduate Program in Biosciences, Federal University of the São Francisco Valley (UNIVASF), Pernambuco 56304-917, PE, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+PR%22">da Silva PR</searchLink>; Postgraduate Program of Dentistry (PPGO), Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.; Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.; Postgraduate Program in Natural Synthetic and Bioactive Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sá+Novaes+Pereira+HN%22">de Sá Novaes Pereira HN</searchLink>; Department of Medicine, Federal University of the São Francisco Valley (UNIVASF), Paulo Afonso 48605-560, BA, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+LVN%22">Dos Santos LVN</searchLink>; Department of Medicine, Faculdade Estácio IDOMED, Juazeiro 48924-999, BA, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Santana+MAD%22">de Santana MAD</searchLink>; Departament of Morphology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+AF%22">Alves AF</searchLink>; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22Pontes+AHO%22">Pontes AHO</searchLink>; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+Gomes+J%22">de Souza Gomes J</searchLink>; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22Felipe+CFB%22">Felipe CFB</searchLink>; Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.; Postgraduate Program in Natural Synthetic and Bioactive Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+DP%22">de Sousa DP</searchLink>; Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22Scotti+MT%22">Scotti MT</searchLink>; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22Scotti+L%22">Scotti L</searchLink>; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101092791%22">International journal of molecular sciences</searchLink> [Int J Mol Sci] 2025 Mar 19; Vol. 26 (6). <i>Date of Electronic Publication: </i>2025 Mar 19.
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