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A fusion protein that targets antigen-loaded extracellular vesicles to B cells enhances antigen-specific T cell expansion.

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Title: A fusion protein that targets antigen-loaded extracellular vesicles to B cells enhances antigen-specific T cell expansion.
Authors: Offens A; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden., Teeuwen L; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden., Gucluler Akpinar G; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden., Steiner L; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden., Kooijmans S; CDL Research, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Metabolic Diseases, Wilhelmina's Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands; Regenerative Medicine Center, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands., Mamand D; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm 14152, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden; Karolinska ATMP Center, Karolinska Institutet, Huddinge, Stockholm, Sweden; Breast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden., Weissinger H; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden., Käll A; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden., Eldh M; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden., Wiklander OPB; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm 14152, Sweden; Karolinska ATMP Center, Karolinska Institutet, Huddinge, Stockholm, Sweden; Breast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden., El-Andaloussi S; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm 14152, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden; Karolinska ATMP Center, Karolinska Institutet, Huddinge, Stockholm, Sweden., Karlsson MCI; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Biomedicum, Solnavägen 9, C7, 17165 Solna, Sweden., Vader P; CDL Research, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., Gabrielsson S; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden. Electronic address: susanne.gabrielsson@ki.se.
Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Jun 10; Vol. 382, pp. 113665. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A fusion protein that targets antigen-loaded extracellular vesicles to B cells enhances antigen-specific T cell expansion.
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  Data: <searchLink fieldCode="AU" term="%22Offens+A%22">Offens A</searchLink>; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Teeuwen+L%22">Teeuwen L</searchLink>; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Gucluler+Akpinar+G%22">Gucluler Akpinar G</searchLink>; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Steiner+L%22">Steiner L</searchLink>; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kooijmans+S%22">Kooijmans S</searchLink>; CDL Research, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Metabolic Diseases, Wilhelmina's Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands; Regenerative Medicine Center, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mamand+D%22">Mamand D</searchLink>; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm 14152, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden; Karolinska ATMP Center, Karolinska Institutet, Huddinge, Stockholm, Sweden; Breast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Weissinger+H%22">Weissinger H</searchLink>; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Käll+A%22">Käll A</searchLink>; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Eldh+M%22">Eldh M</searchLink>; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Wiklander+OPB%22">Wiklander OPB</searchLink>; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm 14152, Sweden; Karolinska ATMP Center, Karolinska Institutet, Huddinge, Stockholm, Sweden; Breast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22El-Andaloussi+S%22">El-Andaloussi S</searchLink>; Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred-Nobels-Allé 8, Huddinge, Stockholm 14152, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden; Karolinska ATMP Center, Karolinska Institutet, Huddinge, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Karlsson+MCI%22">Karlsson MCI</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Biomedicum, Solnavägen 9, C7, 17165 Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Vader+P%22">Vader P</searchLink>; CDL Research, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gabrielsson+S%22">Gabrielsson S</searchLink>; Division of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine (CMM L8:00), Visionsgatan 18, 171 64 Solna, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine (CMM), Stockholm, Sweden. Electronic address: susanne.gabrielsson@ki.se.
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