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Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints.

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Title: Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints.
Authors: Yin X; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China. xianyongyin@njmu.edu.cn., Li J; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Bose D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Okamoto J; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Kwon A; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Fernandes Silva L; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Oravilahti A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Chu X; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Liu L; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China., Peng R; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China., Xia Z; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China., Ripatti S; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT & Harvard, Cambridge, MA, USA., Daly M; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Palotie A; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Burant CF; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Fauman EB; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Wen X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA. boehnke@umich.edu., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. markku.laakso@uef.fi., Morrison J; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA. jvmorr@umich.edu.
Source: Nature communications [Nat Commun] 2025 Mar 28; Vol. 16 (1), pp. 3039. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China. xianyongyin@njmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Bose+D%22">Bose D</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Okamoto+J%22">Okamoto J</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kwon+A%22">Kwon A</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+AU%22">Jackson AU</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Fernandes+Silva+L%22">Fernandes Silva L</searchLink>; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Oravilahti+A%22">Oravilahti A</searchLink>; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Chu+X%22">Chu X</searchLink>; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Stringham+HM%22">Stringham HM</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Peng+R%22">Peng R</searchLink>; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Xia+Z%22">Xia Z</searchLink>; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Ripatti+S%22">Ripatti S</searchLink>; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT & Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Daly+M%22">Daly M</searchLink>; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Palotie+A%22">Palotie A</searchLink>; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Scott+LJ%22">Scott LJ</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Burant+CF%22">Burant CF</searchLink>; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Fauman+EB%22">Fauman EB</searchLink>; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wen+X%22">Wen X</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA. boehnke@umich.edu.<br /><searchLink fieldCode="AU" term="%22Laakso+M%22">Laakso M</searchLink>; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. markku.laakso@uef.fi.<br /><searchLink fieldCode="AU" term="%22Morrison+J%22">Morrison J</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA. jvmorr@umich.edu.
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