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Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials.

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Title: Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials.
Authors: Ossenkoppele R; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. r.ossenkoppele@amsterdamumc.nl.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. r.ossenkoppele@amsterdamumc.nl.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, the Netherlands. r.ossenkoppele@amsterdamumc.nl., Salvadó G; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Pichet Binette A; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Bali D; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Karlsson L; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden., Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Therriault J; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Rahmouni N; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Rosa-Neto P; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Coomans EM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, the Netherlands., van de Giessen E; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., van der Flier WM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Teunissen CE; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Neurochemistry Laboratory, Department of Laboratory Medicine, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Jonaitis EM; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Johnson SC; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Villeneuve S; Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Douglas Mental Health University Institute, Montreal, Quebec, Canada.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Benzinger TLS; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA., Schindler SE; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Bateman RJ; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; The Tracy Family SILQ Center, Washington University School of Medicine, St. Louis, MO, USA., Doecke JD; Australian eHealth Research Centre, Commonwealth Scientific and Industrial Research Organization, Melbourne, Victoria, Australia., Doré V; Australian eHealth Research Centre, Commonwealth Scientific and Industrial Research Organization, Melbourne, Victoria, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia., Feizpour A; Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Parkville, Victoria, Australia., Masters CL; The Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Parkville, Victoria, Australia., Rowe C; Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Parkville, Victoria, Australia., Wiste HJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. oskar.hansson@med.lu.se.; Memory Clinic, Skåne University Hospital, Malmö, Sweden. oskar.hansson@med.lu.se.
Corporate Authors: PREVENT-AD Research Group
Source: Nature aging [Nat Aging] 2025 May; Vol. 5 (5), pp. 883-896. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials.
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  Data: <searchLink fieldCode="AU" term="%22Ossenkoppele+R%22">Ossenkoppele R</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. r.ossenkoppele@amsterdamumc.nl.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. r.ossenkoppele@amsterdamumc.nl.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, the Netherlands. r.ossenkoppele@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Salvadó+G%22">Salvadó G</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Janelidze+S%22">Janelidze S</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Pichet+Binette+A%22">Pichet Binette A</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Bali+D%22">Bali D</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Karlsson+L%22">Karlsson L</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Palmqvist+S%22">Palmqvist S</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Mattsson-Carlgren+N%22">Mattsson-Carlgren N</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Stomrud+E%22">Stomrud E</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Therriault+J%22">Therriault J</searchLink>; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Rahmouni+N%22">Rahmouni N</searchLink>; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Rosa-Neto+P%22">Rosa-Neto P</searchLink>; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Coomans+EM%22">Coomans EM</searchLink>; 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Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Schindler+SE%22">Schindler SE</searchLink>; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bateman+RJ%22">Bateman RJ</searchLink>; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; The Tracy Family SILQ Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Doecke+JD%22">Doecke JD</searchLink>; Australian eHealth Research Centre, Commonwealth Scientific and Industrial Research Organization, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Doré+V%22">Doré V</searchLink>; 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