Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial.
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| Title: | Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial. |
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| Authors: | Omlor W; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Cecere G; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Huang GY; Swiss Federal Institute of Technology Zurich, Zurich, Switzerland., Spiller T; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Misra AR; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Rabe F; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Kallen N; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Kirschner M; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Surbeck W; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Burrer A; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Garibaldi G; Noema Pharma, Basel, Switzerland., Holiga Š; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases (NRD), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, 4070, Switzerland., Dukart J; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, 52428, Germany.; Institute of Systems Neuroscience, Medical Faculty &, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, 40225, Germany., Umbricht D; xperimed GmbH, Basel, Switzerland., Homan P; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland. philipp.homan@bli.uzh.ch.; Neuroscience Center Zurich, University of Zurich & Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. philipp.homan@bli.uzh.ch. |
| Source: | BMC medicine [BMC Med] 2025 Mar 28; Vol. 23 (1), pp. 187. Date of Electronic Publication: 2025 Mar 28. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1741-7015 |
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| DOI: | 10.1186/s12916-025-04004-2 |
