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Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial.

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Title: Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial.
Authors: Omlor W; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Cecere G; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Huang GY; Swiss Federal Institute of Technology Zurich, Zurich, Switzerland., Spiller T; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Misra AR; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Rabe F; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Kallen N; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Kirschner M; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Surbeck W; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Burrer A; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland., Garibaldi G; Noema Pharma, Basel, Switzerland., Holiga Š; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases (NRD), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, 4070, Switzerland., Dukart J; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, 52428, Germany.; Institute of Systems Neuroscience, Medical Faculty &, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, 40225, Germany., Umbricht D; xperimed GmbH, Basel, Switzerland., Homan P; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland. philipp.homan@bli.uzh.ch.; Neuroscience Center Zurich, University of Zurich & Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. philipp.homan@bli.uzh.ch.
Source: BMC medicine [BMC Med] 2025 Mar 28; Vol. 23 (1), pp. 187. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial.
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  Data: <searchLink fieldCode="AU" term="%22Omlor+W%22">Omlor W</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cecere+G%22">Cecere G</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.<br /><searchLink fieldCode="AU" term="%22Huang+GY%22">Huang GY</searchLink>; Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Spiller+T%22">Spiller T</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.<br /><searchLink fieldCode="AU" term="%22Misra+AR%22">Misra AR</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rabe+F%22">Rabe F</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kallen+N%22">Kallen N</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kirschner+M%22">Kirschner M</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Surbeck+W%22">Surbeck W</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.<br /><searchLink fieldCode="AU" term="%22Burrer+A%22">Burrer A</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland.<br /><searchLink fieldCode="AU" term="%22Garibaldi+G%22">Garibaldi G</searchLink>; Noema Pharma, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Holiga+Š%22">Holiga Š</searchLink>; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases (NRD), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, 4070, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dukart+J%22">Dukart J</searchLink>; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, 52428, Germany.; Institute of Systems Neuroscience, Medical Faculty &, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, 40225, Germany.<br /><searchLink fieldCode="AU" term="%22Umbricht+D%22">Umbricht D</searchLink>; xperimed GmbH, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Homan+P%22">Homan P</searchLink>; Psychiatric Hospital, University of Zurich, Lenggstrasse 31, Zurich, 8032, Switzerland. philipp.homan@bli.uzh.ch.; Neuroscience Center Zurich, University of Zurich & Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. philipp.homan@bli.uzh.ch.
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  Data: <searchLink fieldCode="JN" term="%22101190723%22">BMC medicine</searchLink> [BMC Med] 2025 Mar 28; Vol. 23 (1), pp. 187. <i>Date of Electronic Publication: </i>2025 Mar 28.
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