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Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.

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Title: Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Authors: Xu Y; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Institute of Urology, Anhui Medical University, Hefei, China.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China., You J; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Institute of Urology, Anhui Medical University, Hefei, China.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China., Yao J; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Institute of Urology, Anhui Medical University, Hefei, China.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China., Hou B; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. binggoaza@163.com.; Institute of Urology, Anhui Medical University, Hefei, China. binggoaza@163.com.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China. binggoaza@163.com., Wang W; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. wangweimiwai@126.com.; Institute of Urology, Anhui Medical University, Hefei, China. wangweimiwai@126.com.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China. wangweimiwai@126.com.; Department of Urology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China. wangweimiwai@126.com., Hao Z; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. haozongyao@ahmu.edu.cn.; Institute of Urology, Anhui Medical University, Hefei, China. haozongyao@ahmu.edu.cn.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China. haozongyao@ahmu.edu.cn.
Source: Urolithiasis [Urolithiasis] 2025 Mar 29; Vol. 53 (1), pp. 61. Date of Electronic Publication: 2025 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 101602699 Publication Model: Electronic Cited Medium: Internet ISSN: 2194-7236 (Electronic) Linking ISSN: 21947228 NLM ISO Abbreviation: Urolithiasis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
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  Data: <searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Institute of Urology, Anhui Medical University, Hefei, China.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China.<br /><searchLink fieldCode="AU" term="%22You+J%22">You J</searchLink>; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Institute of Urology, Anhui Medical University, Hefei, China.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Institute of Urology, Anhui Medical University, Hefei, China.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Hou+B%22">Hou B</searchLink>; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. binggoaza@163.com.; Institute of Urology, Anhui Medical University, Hefei, China. binggoaza@163.com.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China. binggoaza@163.com.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. wangweimiwai@126.com.; Institute of Urology, Anhui Medical University, Hefei, China. wangweimiwai@126.com.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China. wangweimiwai@126.com.; Department of Urology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China. wangweimiwai@126.com.<br /><searchLink fieldCode="AU" term="%22Hao+Z%22">Hao Z</searchLink>; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. haozongyao@ahmu.edu.cn.; Institute of Urology, Anhui Medical University, Hefei, China. haozongyao@ahmu.edu.cn.; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China. haozongyao@ahmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101602699%22">Urolithiasis</searchLink> [Urolithiasis] 2025 Mar 29; Vol. 53 (1), pp. 61. <i>Date of Electronic Publication: </i>2025 Mar 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101602699 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2194-7236 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221947228%22">21947228 </searchLink><i>NLM ISO Abbreviation: </i>Urolithiasis <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00240-025-01734-z
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              Text: 2025 Mar 29
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