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Buffered salt solution versus 0.9% sodium chloride as fluid therapy for patients presenting with moderate to severe diabetic ketoacidosis: Study protocol for a Phase-3 cluster-crossover, blinded, randomised, controlled trial.

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Title: Buffered salt solution versus 0.9% sodium chloride as fluid therapy for patients presenting with moderate to severe diabetic ketoacidosis: Study protocol for a Phase-3 cluster-crossover, blinded, randomised, controlled trial.
Authors: Ramanan M; Intensive Care Services, Caboolture and Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Rajbhandari D; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia., Koch C; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia., Abdelhamid YA; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia.; University of Melbourne, Melbourne Medical School, Department of Critical Care, Parkville, Victoria, Australia., Attokaran A; Intensive Care Unit, Rockhampton Hospital, Rockhampton, Queensland, Australia.; Rural Clinical School, University of Queensland, Rockhampton, Queensland, Australia., Billot L; Statistics Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Bompoint S; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia., Cohen J; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; School of Medicine, University of Queensland, St Lucia, Brisbane, Queensland, Australia.; The Wesley and Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Delaney A; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Intensive Care Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia., Devaux A; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia., Ekinci E; Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.; Austin Health, Heidelberg, Victoria, Australia., Finfer S; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Intensive Care Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.; School of Public Health, Faculty of Medicine, Imperial College London, London, UK., Garside T; Intensive Care Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.; University of Sydney, Sydney, New South Wales, Australia., Hammond N; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Royal North Shore Hospital, St Leonards, New South Wales, Australia., Higgins A; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Australia New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia., Keijzers G; Emergency Department, Gold Coast University Hospital, Gold Coast, Australia.; School of Medicine, Griffith University, Gold Coast, Australia.; Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia., Li Q; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia., Moran B; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Department of Intensive Care and Department of Anaesthesia and Pain Medicine, Gosford Hospital, Gosford, New South Wales, Australia.; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Myburgh J; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Intensive Care Department, St George Hospital, Kogarah, New South Wales, Australia., Nair P; Intensive Care Services, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia., Peake S; Intensive Care Unit, The Queen Elizabeth Hospital, Woodville, South Australia, Australia.; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia., Russell A; School of Public Health and Preventative Medicine, Monash University, Clayton, Victoria, Australia., Tabah A; Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.; Intensive Care Unit, Redcliffe Hospital, Redcliffe, Queensland, Australia., Watts S; Department of Emergency Medicine, Caboolture Hospital, Caboolture, Queensland, Australia., Venkatesh B; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Gold Coast University Hospital, Southport, Queensland, Australia.
Source: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine [Crit Care Resusc] 2025 Mar 13; Vol. 27 (1), pp. 100104. Date of Electronic Publication: 2025 Mar 13 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V. on behalf of College of Intensive Care Medicine of Australia and New Zealand Country of Publication: Netherlands NLM ID: 100888170 Publication Model: eCollection Cited Medium: Print ISSN: 1441-2772 (Print) Linking ISSN: 14412772 NLM ISO Abbreviation: Crit Care Resusc Subsets: PubMed not MEDLINE
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  Data: Buffered salt solution versus 0.9% sodium chloride as fluid therapy for patients presenting with moderate to severe diabetic ketoacidosis: Study protocol for a Phase-3 cluster-crossover, blinded, randomised, controlled trial.
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Emergency Department, Gold Coast University Hospital, Gold Coast, Australia.; School of Medicine, Griffith University, Gold Coast, Australia.; Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Moran+B%22">Moran B</searchLink>; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Department of Intensive Care and Department of Anaesthesia and Pain Medicine, Gosford Hospital, Gosford, New South Wales, Australia.; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Myburgh+J%22">Myburgh J</searchLink>; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; 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Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; Gold Coast University Hospital, Southport, Queensland, Australia.
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