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Targeted Normoxemia and Supplemental Oxygen-Free Days in Critically Injured Adults: A Stepped-Wedge Cluster Randomized Clinical Trial.

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Title: Targeted Normoxemia and Supplemental Oxygen-Free Days in Critically Injured Adults: A Stepped-Wedge Cluster Randomized Clinical Trial.
Authors: Douin DJ; Department of Anesthesiology, University of Colorado School of Medicine, Aurora., Rice JD; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor., Anderson EL; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora., Jackson CL; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora., Cheng AC; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Xiao M; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora., Cwik J; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora., Beaty LE; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora., Wild JL; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora., Daya MR; Department of Emergency Medicine, Oregon Health & Science University, Portland., Doshi PB; Department of Emergency Medicine, McGovern Medical School at The University of Texas Health Science Center, Houston., Eastham SC; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee., Goodman MD; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio., Gunn SR; Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Haukoos JS; Department of Emergency Medicine, Denver Health Medical Center, Denver, Colorado., Hudson JA; Department of Emergency Medicine, McGovern Medical School at The University of Texas Health Science Center, Houston., Jansen JO; Department of Surgery, University of Alabama at Birmingham, Birmingham., McMullan JT; Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio., Rizzo JA; Department of Surgery, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas., Schreiber MA; Donald D. Trunkey Center for Civilian and Combat Casualty Care, Oregon Health & Science University, Portland., Self WH; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Semler MW; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Steinwand A; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora., Werner N; Department of Surgery, Denver Health Medical Center, Denver, Colorado.; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison., Bebarta VS; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.; Center for Combat Medicine and Battlefield Research, University of Colorado School of Medicine, Aurora., Schauer SG; US Army Institute of Surgical Research, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas.; Department of Emergency Medicine, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas., Ginde AA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.
Corporate Authors: Strategy to Avoid Excessive Oxygen (SAVE-O2) Investigators
Source: JAMA network open [JAMA Netw Open] 2025 Mar 03; Vol. 8 (3), pp. e252093. Date of Electronic Publication: 2025 Mar 03.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Douin+DJ%22">Douin DJ</searchLink>; Department of Anesthesiology, University of Colorado School of Medicine, Aurora.<br /><searchLink fieldCode="AU" term="%22Rice+JD%22">Rice JD</searchLink>; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor.<br /><searchLink fieldCode="AU" term="%22Anderson+EL%22">Anderson EL</searchLink>; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.<br /><searchLink fieldCode="AU" term="%22Jackson+CL%22">Jackson CL</searchLink>; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Cheng+AC%22">Cheng AC</searchLink>; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Xiao+M%22">Xiao M</searchLink>; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Cwik+J%22">Cwik J</searchLink>; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.<br /><searchLink fieldCode="AU" term="%22Beaty+LE%22">Beaty LE</searchLink>; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Wild+JL%22">Wild JL</searchLink>; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Daya+MR%22">Daya MR</searchLink>; Department of Emergency Medicine, Oregon Health & Science University, Portland.<br /><searchLink fieldCode="AU" term="%22Doshi+PB%22">Doshi PB</searchLink>; Department of Emergency Medicine, McGovern Medical School at The University of Texas Health Science Center, Houston.<br /><searchLink fieldCode="AU" term="%22Eastham+SC%22">Eastham SC</searchLink>; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Goodman+MD%22">Goodman MD</searchLink>; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Gunn+SR%22">Gunn SR</searchLink>; Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Haukoos+JS%22">Haukoos JS</searchLink>; Department of Emergency Medicine, Denver Health Medical Center, Denver, Colorado.<br /><searchLink fieldCode="AU" term="%22Hudson+JA%22">Hudson JA</searchLink>; Department of Emergency Medicine, McGovern Medical School at The University of Texas Health Science Center, Houston.<br /><searchLink fieldCode="AU" term="%22Jansen+JO%22">Jansen JO</searchLink>; Department of Surgery, University of Alabama at Birmingham, Birmingham.<br /><searchLink fieldCode="AU" term="%22McMullan+JT%22">McMullan JT</searchLink>; Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Rizzo+JA%22">Rizzo JA</searchLink>; Department of Surgery, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Schreiber+MA%22">Schreiber MA</searchLink>; Donald D. Trunkey Center for Civilian and Combat Casualty Care, Oregon Health & Science University, Portland.<br /><searchLink fieldCode="AU" term="%22Self+WH%22">Self WH</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Semler+MW%22">Semler MW</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Steinwand+A%22">Steinwand A</searchLink>; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.<br /><searchLink fieldCode="AU" term="%22Werner+N%22">Werner N</searchLink>; Department of Surgery, Denver Health Medical Center, Denver, Colorado.; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison.<br /><searchLink fieldCode="AU" term="%22Bebarta+VS%22">Bebarta VS</searchLink>; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.; Center for Combat Medicine and Battlefield Research, University of Colorado School of Medicine, Aurora.<br /><searchLink fieldCode="AU" term="%22Schauer+SG%22">Schauer SG</searchLink>; US Army Institute of Surgical Research, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas.; Department of Emergency Medicine, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Ginde+AA%22">Ginde AA</searchLink>; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.
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  Data: <searchLink fieldCode="JN" term="%22101729235%22">JAMA network open</searchLink> [JAMA Netw Open] 2025 Mar 03; Vol. 8 (3), pp. e252093. <i>Date of Electronic Publication: </i>2025 Mar 03.
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  Data: Journal Article; Randomized Controlled Trial; Multicenter Study; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101729235 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2574-3805 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225743805%22">25743805 </searchLink><i>NLM ISO Abbreviation: </i>JAMA Netw Open <i>Subsets: </i>MEDLINE
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