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AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling.

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Title: AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling.
Authors: Zähringer A; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Morgado I; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Erny D; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Ingelfinger F; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Gawron J; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Chatterjee S; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Wenger V; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schmidt D; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Schwöbel L; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Adams RC; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA., Langenbach M; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Hartmann A; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Osswald N; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Wolf J; Department of Ophthalmology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schlunck G; Department of Ophthalmology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Briquez PS; Department of General and Visceral Surgery, Center for Surgery, Medical Center University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.; Signaling Research Centers BIOSS and CIBSS, Center for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany., Grueter K; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Ruess DA; Department of General and Visceral Surgery, Center for Surgery, Medical Center University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, a partnership between DKFZ and Medical Center University of Freiburg, Freiburg, Germany., Frew I; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Burk AC; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, a partnership between DKFZ and Medical Center University of Freiburg, Freiburg, Germany., Holzmüller V; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany., Grimbacher B; Center for Chronic Immunodeficiency CCI, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Michonneau D; Department of Hematology, Hôpitaux Universitaires Saint-Louis, Paris, France.; Hematology and Transplantation Unit, Saint-Louis Hospital, APHP, Paris, France.; INSERM UMR1342 Saint-Louis Research Institute, Team Translational Immunology in Immunotherapies and Hematology, IHU Leukemia Institute Paris Saint-Louis, Paris Cité University, Paris, France., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Socié G; Department of Hematology, Hôpitaux Universitaires Saint-Louis, Paris, France.; Hematology and Transplantation Unit, Saint-Louis Hospital, APHP, Paris, France.; INSERM UMR1342 Saint-Louis Research Institute, Team Translational Immunology in Immunotherapies and Hematology, IHU Leukemia Institute Paris Saint-Louis, Paris Cité University, Paris, France., Kolter J; Center for Chronic Immunodeficiency CCI, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute for Infection Prevention and Control, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Boerries M; Signaling Research Centers BIOSS and CIBSS, Center for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Follo M; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Blaeschke F; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital (UKHD), Heidelberg, Germany., Sevenich L; Department of Neurology and Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research (HIH) and M3 Research Center, University Hospital Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany., Prinz M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signaling Research Centers BIOSS and CIBSS, Center for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany., Zeiser R; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signaling Research Centers BIOSS and CIBSS, Center for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany., Vinnakota JM; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Source: Blood advances [Blood Adv] 2025 Jun 24; Vol. 9 (12), pp. 2935-2952.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling.
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Department of General and Visceral Surgery, Center for Surgery, Medical Center University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.; Signaling Research Centers BIOSS and CIBSS, Center for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Grueter+K%22">Grueter K</searchLink>; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ruess+DA%22">Ruess DA</searchLink>; Department of General and Visceral Surgery, Center for Surgery, Medical Center University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, a partnership between DKFZ and Medical Center University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Frew+I%22">Frew I</searchLink>; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Burk+AC%22">Burk AC</searchLink>; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, a partnership between DKFZ and Medical Center University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Holzmüller+V%22">Holzmüller V</searchLink>; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Grimbacher+B%22">Grimbacher B</searchLink>; Center for Chronic Immunodeficiency CCI, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Michonneau+D%22">Michonneau D</searchLink>; Department of Hematology, Hôpitaux Universitaires Saint-Louis, Paris, France.; Hematology and Transplantation Unit, Saint-Louis Hospital, APHP, Paris, France.; INSERM UMR1342 Saint-Louis Research Institute, Team Translational Immunology in Immunotherapies and Hematology, IHU Leukemia Institute Paris Saint-Louis, Paris Cité University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Andrieux+G%22">Andrieux G</searchLink>; Institute of Medical Bioinformatics and Systems Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Socié+G%22">Socié G</searchLink>; Department of Hematology, Hôpitaux Universitaires Saint-Louis, Paris, France.; Hematology and Transplantation Unit, Saint-Louis Hospital, APHP, Paris, France.; INSERM UMR1342 Saint-Louis Research Institute, Team Translational Immunology in Immunotherapies and Hematology, IHU Leukemia Institute Paris Saint-Louis, Paris Cité University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Kolter+J%22">Kolter J</searchLink>; Center for Chronic Immunodeficiency CCI, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute for Infection Prevention and Control, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boerries+M%22">Boerries M</searchLink>; Signaling Research Centers BIOSS and CIBSS, Center for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Follo+M%22">Follo M</searchLink>; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Blaeschke+F%22">Blaeschke F</searchLink>; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital (UKHD), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sevenich+L%22">Sevenich L</searchLink>; Department of Neurology and Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research (HIH) and M3 Research Center, University Hospital Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Prinz+M%22">Prinz M</searchLink>; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signaling Research Centers BIOSS and CIBSS, Center for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeiser+R%22">Zeiser R</searchLink>; Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signaling Research Centers BIOSS and CIBSS, Center for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vinnakota+JM%22">Vinnakota JM</searchLink>; 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