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Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation.

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Title: Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation.
Authors: Sherry L; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. L.W.Sherry@leeds.ac.uk., Grehan K; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Bahar MW; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK., Swanson JJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Fox H; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, EN6 3QG, UK., Matthews S; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Carlyle S; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, EN6 3QG, UK., Qin L; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK., Porta C; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK., Wilkinson S; CPI, 1 Union Square, Central Park, Darlington, DL1 1GL, UK., Robb S; CPI, 1 Union Square, Central Park, Darlington, DL1 1GL, UK., Clark N; CPI, 1 Union Square, Central Park, Darlington, DL1 1GL, UK., Liddell J; CPI, 1 Union Square, Central Park, Darlington, DL1 1GL, UK., Fry EE; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK., Stuart DI; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, OX3 7BN, UK., Macadam AJ; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, EN6 3QG, UK., Rowlands DJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. D.J.Rowlands@leeds.ac.uk., Stonehouse NJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. N.J.Stonehouse@leeds.ac.uk.
Source: NPJ vaccines [NPJ Vaccines] 2025 Mar 31; Vol. 10 (1), pp. 64. Date of Electronic Publication: 2025 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Sherry+L%22">Sherry L</searchLink>; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. L.W.Sherry@leeds.ac.uk.<br /><searchLink fieldCode="AU" term="%22Grehan+K%22">Grehan K</searchLink>; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Bahar+MW%22">Bahar MW</searchLink>; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Swanson+JJ%22">Swanson JJ</searchLink>; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Fox+H%22">Fox H</searchLink>; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, EN6 3QG, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+S%22">Matthews S</searchLink>; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Carlyle+S%22">Carlyle S</searchLink>; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, EN6 3QG, UK.<br /><searchLink fieldCode="AU" term="%22Qin+L%22">Qin L</searchLink>; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Porta+C%22">Porta C</searchLink>; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Wilkinson+S%22">Wilkinson S</searchLink>; CPI, 1 Union Square, Central Park, Darlington, DL1 1GL, UK.<br /><searchLink fieldCode="AU" term="%22Robb+S%22">Robb S</searchLink>; CPI, 1 Union Square, Central Park, Darlington, DL1 1GL, UK.<br /><searchLink fieldCode="AU" term="%22Clark+N%22">Clark N</searchLink>; CPI, 1 Union Square, Central Park, Darlington, DL1 1GL, UK.<br /><searchLink fieldCode="AU" term="%22Liddell+J%22">Liddell J</searchLink>; CPI, 1 Union Square, Central Park, Darlington, DL1 1GL, UK.<br /><searchLink fieldCode="AU" term="%22Fry+EE%22">Fry EE</searchLink>; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Stuart+DI%22">Stuart DI</searchLink>; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, OX3 7BN, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Macadam+AJ%22">Macadam AJ</searchLink>; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, EN6 3QG, UK.<br /><searchLink fieldCode="AU" term="%22Rowlands+DJ%22">Rowlands DJ</searchLink>; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. D.J.Rowlands@leeds.ac.uk.<br /><searchLink fieldCode="AU" term="%22Stonehouse+NJ%22">Stonehouse NJ</searchLink>; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. N.J.Stonehouse@leeds.ac.uk.
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