The PH domain in the ArfGAP ASAP1 drives catalytic activation through an unprecedented allosteric mechanism.
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| Title: | The PH domain in the ArfGAP ASAP1 drives catalytic activation through an unprecedented allosteric mechanism. |
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| Authors: | Soubias O; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Foley SL; Department of Biophysics, The Johns Hopkins University, Baltimore, MD, USA., Jian X; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Jackson RA; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Zhang Y; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Rosenberg EM Jr; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Li J; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Heinrich F; Department of Physics Carnegie Mellon University, Pittsburgh, PA, USA NIST Center for Neutron Research, Gaithersburg, MD, USA.; Department of Physics Carnegie Mellon University, Pittsburgh, PA, USA NIST Center for Neutron Research, Gaithersburg, MD, USA., Johnson ME; Department of Biophysics, The Johns Hopkins University, Baltimore, MD, USA., Sodt AJ; Unit of Membrane Chemical Physics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Randazzo PA; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Byrd RA; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. |
| Source: | Research square [Res Sq] 2025 Mar 19. Date of Electronic Publication: 2025 Mar 19. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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