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Acetylshikonin induces cell necroptosis via mediating mitochondrial function and oxidative stress-regulated signaling in human Oral Cancer cells.

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Title: Acetylshikonin induces cell necroptosis via mediating mitochondrial function and oxidative stress-regulated signaling in human Oral Cancer cells.
Authors: Shao KY; Oral-Maxillofacial Surgery Division, Department of Dentistry, Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan., Luo SD; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Taiwan; School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; School of Medicine, College of Medicine, National SunYat-sen University, Kaohsiung, Taiwan., Huang EY; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, Taiwan; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung City, Taiwan., Chang TM; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan., Botcha L; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan., Sehar M; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan., Liu JF; School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: jufangliu@tmu.edu.tw., Chuang PK; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: pkchuang@mail.nsysu.edu.tw.
Source: Bioorganic chemistry [Bioorg Chem] 2025 Jun 01; Vol. 159, pp. 108396. Date of Electronic Publication: 2025 Mar 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Acetylshikonin induces cell necroptosis via mediating mitochondrial function and oxidative stress-regulated signaling in human Oral Cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Shao+KY%22">Shao KY</searchLink>; Oral-Maxillofacial Surgery Division, Department of Dentistry, Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Luo+SD%22">Luo SD</searchLink>; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Taiwan; School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; School of Medicine, College of Medicine, National SunYat-sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+EY%22">Huang EY</searchLink>; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, Taiwan; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+TM%22">Chang TM</searchLink>; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Botcha+L%22">Botcha L</searchLink>; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sehar+M%22">Sehar M</searchLink>; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+JF%22">Liu JF</searchLink>; School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: jufangliu@tmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chuang+PK%22">Chuang PK</searchLink>; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: pkchuang@mail.nsysu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2025 Jun 01; Vol. 159, pp. 108396. <i>Date of Electronic Publication: </i>2025 Mar 21.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bioorg.2025.108396
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        Text: English
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              Text: 2025 Jun 01
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              Y: 2025
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