View in EDS

TIMEPOINT, a phase 1 study combining MTL-CEBPA with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumors.

Saved in:
Bibliographic Details
Title: TIMEPOINT, a phase 1 study combining MTL-CEBPA with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumors.
Authors: Plummer R; The Northern Centre for Cancer Care, Freeman Hospital, NE7 7DN Newcastle, UK., Sodergren MH; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK., Hodgson R; MiNA Therapeutics Ltd, W12 0BZ London, UK., Ryan BM; MiNA Therapeutics Ltd, W12 0BZ London, UK., Raulf N; MiNA Therapeutics Ltd, W12 0BZ London, UK., Nicholls JP; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK; MiNA Therapeutics Ltd, W12 0BZ London, UK., Reebye V; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK; MiNA Therapeutics Ltd, W12 0BZ London, UK., Voutila J; MiNA Therapeutics Ltd, W12 0BZ London, UK., Sinigaglia L; MiNA Therapeutics Ltd, W12 0BZ London, UK., Meyer T; Research Department of Oncology, UCL Cancer Institute, University College London, WC1E 6DD London, UK., Pinato DJ; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK; Department of Translational Medicine (DIMET), Università Del Piemonte Orientale 'A. Avogadro', Novara, Italy., Sarker D; Department of Research Oncology, Guys Hospital, Kings College London, SE1 9RT London, UK., Basu B; University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK., Blagden S; Department of Oncology, Oxford University, Churchill Hospital, OX3 7LE Oxford, UK., Cook N; University of Manchester and The Christie NHS Foundation Trust, M20 4BX Manchester, UK., Jeffrey Evans TR; The Beatson West of Scotland Cancer Centre, University of Glasgow, G12 0YN Glasgow, UK., Yachnin J; Centrum Kliniska Cancerstudier, Karolinska University Hospital, 17176 Stockholm, Sweden., Chee CE; National University Hospital, National University Cancer Institute Singapore, Singapore 11928, Singapore., Li D; Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., El-Khoueiry A; Norris Comprehensive Cancer Centre, Keck Medicine, University of Southern California, Los Angeles, CA 90089, USA., Diab M; Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA., Huang KW; National Taiwan University Hospital, Taipei, Taiwan., Pai M; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK., Spalding D; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK., Talbot T; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK., Noel MS; Medstar Georgetown University Hospital, Washington, DC 20007, USA., Keenan B; University of California San Francisco, San Francisco, CA 94143, USA., Mahalingam D; Robert H Lurie Comprehensive Cancer Centre, Northwestern University, Chicago, IL 60611, USA., Song MS; Beckman Research Institute, City of Hope, CA, USA., Grosso M; Veracyte, Marseilles, France., Arnaud D; Veracyte, Marseilles, France., Auguste A; Veracyte, Marseilles, France., Zacharoulis D; Department of General Surgery, University Hospital of Larissa, Larissa, Greece., Storkholm J; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK., McNeish I; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK., Habib R; MiNA Therapeutics Ltd, W12 0BZ London, UK., Rossi JJ; Beckman Research Institute, City of Hope, CA, USA., Habib NA; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK; MiNA Therapeutics Ltd, W12 0BZ London, UK. Electronic address: nagy.habib@imperial.ac.uk.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Apr 15; Vol. 6 (4), pp. 102041. Date of Electronic Publication: 2025 Mar 31.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40168999
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: TIMEPOINT, a phase 1 study combining MTL-CEBPA with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumors.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Plummer+R%22">Plummer R</searchLink>; The Northern Centre for Cancer Care, Freeman Hospital, NE7 7DN Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Sodergren+MH%22">Sodergren MH</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK.<br /><searchLink fieldCode="AU" term="%22Hodgson+R%22">Hodgson R</searchLink>; MiNA Therapeutics Ltd, W12 0BZ London, UK.<br /><searchLink fieldCode="AU" term="%22Ryan+BM%22">Ryan BM</searchLink>; MiNA Therapeutics Ltd, W12 0BZ London, UK.<br /><searchLink fieldCode="AU" term="%22Raulf+N%22">Raulf N</searchLink>; MiNA Therapeutics Ltd, W12 0BZ London, UK.<br /><searchLink fieldCode="AU" term="%22Nicholls+JP%22">Nicholls JP</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK; MiNA Therapeutics Ltd, W12 0BZ London, UK.<br /><searchLink fieldCode="AU" term="%22Reebye+V%22">Reebye V</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK; MiNA Therapeutics Ltd, W12 0BZ London, UK.<br /><searchLink fieldCode="AU" term="%22Voutila+J%22">Voutila J</searchLink>; MiNA Therapeutics Ltd, W12 0BZ London, UK.<br /><searchLink fieldCode="AU" term="%22Sinigaglia+L%22">Sinigaglia L</searchLink>; MiNA Therapeutics Ltd, W12 0BZ London, UK.<br /><searchLink fieldCode="AU" term="%22Meyer+T%22">Meyer T</searchLink>; Research Department of Oncology, UCL Cancer Institute, University College London, WC1E 6DD London, UK.<br /><searchLink fieldCode="AU" term="%22Pinato+DJ%22">Pinato DJ</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK; Department of Translational Medicine (DIMET), Università Del Piemonte Orientale 'A. Avogadro', Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Sarker+D%22">Sarker D</searchLink>; Department of Research Oncology, Guys Hospital, Kings College London, SE1 9RT London, UK.<br /><searchLink fieldCode="AU" term="%22Basu+B%22">Basu B</searchLink>; University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Blagden+S%22">Blagden S</searchLink>; Department of Oncology, Oxford University, Churchill Hospital, OX3 7LE Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cook+N%22">Cook N</searchLink>; University of Manchester and The Christie NHS Foundation Trust, M20 4BX Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Jeffrey+Evans+TR%22">Jeffrey Evans TR</searchLink>; The Beatson West of Scotland Cancer Centre, University of Glasgow, G12 0YN Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Yachnin+J%22">Yachnin J</searchLink>; Centrum Kliniska Cancerstudier, Karolinska University Hospital, 17176 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Chee+CE%22">Chee CE</searchLink>; National University Hospital, National University Cancer Institute Singapore, Singapore 11928, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.<br /><searchLink fieldCode="AU" term="%22El-Khoueiry+A%22">El-Khoueiry A</searchLink>; Norris Comprehensive Cancer Centre, Keck Medicine, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Diab+M%22">Diab M</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Huang+KW%22">Huang KW</searchLink>; National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Pai+M%22">Pai M</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK.<br /><searchLink fieldCode="AU" term="%22Spalding+D%22">Spalding D</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK.<br /><searchLink fieldCode="AU" term="%22Talbot+T%22">Talbot T</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK.<br /><searchLink fieldCode="AU" term="%22Noel+MS%22">Noel MS</searchLink>; Medstar Georgetown University Hospital, Washington, DC 20007, USA.<br /><searchLink fieldCode="AU" term="%22Keenan+B%22">Keenan B</searchLink>; University of California San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Mahalingam+D%22">Mahalingam D</searchLink>; Robert H Lurie Comprehensive Cancer Centre, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Song+MS%22">Song MS</searchLink>; Beckman Research Institute, City of Hope, CA, USA.<br /><searchLink fieldCode="AU" term="%22Grosso+M%22">Grosso M</searchLink>; Veracyte, Marseilles, France.<br /><searchLink fieldCode="AU" term="%22Arnaud+D%22">Arnaud D</searchLink>; Veracyte, Marseilles, France.<br /><searchLink fieldCode="AU" term="%22Auguste+A%22">Auguste A</searchLink>; Veracyte, Marseilles, France.<br /><searchLink fieldCode="AU" term="%22Zacharoulis+D%22">Zacharoulis D</searchLink>; Department of General Surgery, University Hospital of Larissa, Larissa, Greece.<br /><searchLink fieldCode="AU" term="%22Storkholm+J%22">Storkholm J</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK.<br /><searchLink fieldCode="AU" term="%22McNeish+I%22">McNeish I</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK.<br /><searchLink fieldCode="AU" term="%22Habib+R%22">Habib R</searchLink>; MiNA Therapeutics Ltd, W12 0BZ London, UK.<br /><searchLink fieldCode="AU" term="%22Rossi+JJ%22">Rossi JJ</searchLink>; Beckman Research Institute, City of Hope, CA, USA.<br /><searchLink fieldCode="AU" term="%22Habib+NA%22">Habib NA</searchLink>; Department of Surgery & Cancer, Imperial College London, W12 0NN London, UK; MiNA Therapeutics Ltd, W12 0BZ London, UK. Electronic address: nagy.habib@imperial.ac.uk.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2025 Apr 15; Vol. 6 (4), pp. 102041. <i>Date of Electronic Publication: </i>2025 Mar 31.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Clinical Trial, Phase I
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101766894 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-3791 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226663791%22">26663791 </searchLink><i>NLM ISO Abbreviation: </i>Cell Rep Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40168999
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.xcrm.2025.102041
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 102041
    Titles:
      – TitleFull: TIMEPOINT, a phase 1 study combining MTL-CEBPA with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumors.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Plummer R
      – PersonEntity:
          Name:
            NameFull: Sodergren MH
      – PersonEntity:
          Name:
            NameFull: Hodgson R
      – PersonEntity:
          Name:
            NameFull: Ryan BM
      – PersonEntity:
          Name:
            NameFull: Raulf N
      – PersonEntity:
          Name:
            NameFull: Nicholls JP
      – PersonEntity:
          Name:
            NameFull: Reebye V
      – PersonEntity:
          Name:
            NameFull: Voutila J
      – PersonEntity:
          Name:
            NameFull: Sinigaglia L
      – PersonEntity:
          Name:
            NameFull: Meyer T
      – PersonEntity:
          Name:
            NameFull: Pinato DJ
      – PersonEntity:
          Name:
            NameFull: Sarker D
      – PersonEntity:
          Name:
            NameFull: Basu B
      – PersonEntity:
          Name:
            NameFull: Blagden S
      – PersonEntity:
          Name:
            NameFull: Cook N
      – PersonEntity:
          Name:
            NameFull: Jeffrey Evans TR
      – PersonEntity:
          Name:
            NameFull: Yachnin J
      – PersonEntity:
          Name:
            NameFull: Chee CE
      – PersonEntity:
          Name:
            NameFull: Li D
      – PersonEntity:
          Name:
            NameFull: El-Khoueiry A
      – PersonEntity:
          Name:
            NameFull: Diab M
      – PersonEntity:
          Name:
            NameFull: Huang KW
      – PersonEntity:
          Name:
            NameFull: Pai M
      – PersonEntity:
          Name:
            NameFull: Spalding D
      – PersonEntity:
          Name:
            NameFull: Talbot T
      – PersonEntity:
          Name:
            NameFull: Noel MS
      – PersonEntity:
          Name:
            NameFull: Keenan B
      – PersonEntity:
          Name:
            NameFull: Mahalingam D
      – PersonEntity:
          Name:
            NameFull: Song MS
      – PersonEntity:
          Name:
            NameFull: Grosso M
      – PersonEntity:
          Name:
            NameFull: Arnaud D
      – PersonEntity:
          Name:
            NameFull: Auguste A
      – PersonEntity:
          Name:
            NameFull: Zacharoulis D
      – PersonEntity:
          Name:
            NameFull: Storkholm J
      – PersonEntity:
          Name:
            NameFull: McNeish I
      – PersonEntity:
          Name:
            NameFull: Habib R
      – PersonEntity:
          Name:
            NameFull: Rossi JJ
      – PersonEntity:
          Name:
            NameFull: Habib NA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 04
              Text: 2025 Apr 15
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2666-3791
          Numbering:
            – Type: volume
              Value: 6
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Cell reports. Medicine
              Type: main
ResultId 1