View in EDS HTML Full Text PDF Full Text

Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease.

Saved in:
Bibliographic Details
Title: Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease.
Authors: Sobrino S; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France.; Laboratory of Human Lymphohematopoiesis, INSERM, Imagine Institute, Paris, France., Joseph L; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France., Magrin E; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France., Chalumeau A; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France., Hebert N; Univ Paris Est Créteil, IMRB, Laboratory of Excellence LABEX GRex, Créteil, France.; Etablissement Français du Sang, Créteil, France., Corsia A; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France., Denis A; Laboratory of Human Lymphohematopoiesis, INSERM, Imagine Institute, Paris, France., Roudaut C; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France., Aussel C; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France., Leblanc O; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France., Brusson M; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France., Felix T; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France., Diana JS; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France., Petrichenko A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., El Etri J; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France.; Laboratory of Human Lymphohematopoiesis, INSERM, Imagine Institute, Paris, France., Godard A; Aix Marseille Univ, CNRS, EFS, ADES, Labex GR-Ex, Marseille, France., Tibi E; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France., Manceau S; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France., Treluyer JM; Centre d'Investigation Clinique-Unité de Recherche Clinique, Hôpital Universitaire Necker Enfants-Malades, GH Paris Centre, Paris, France.; Université Paris Cité, Paris, France., Mavilio F; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Bushman FD; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Marcais A; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France., Castelle M; Pediatric Immunology and Hematology Department, Hôpital Necker Enfants-Malades, Paris, France., Neven B; Pediatric Immunology and Hematology Department, Hôpital Necker Enfants-Malades, Paris, France., Hermine O; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France., Renolleau S; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France., Magnani A; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France., Asnafi V; Laboratory of Onco-Hematology, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France., El Nemer W; Aix Marseille Univ, CNRS, EFS, ADES, Labex GR-Ex, Marseille, France., Bartolucci P; Univ Paris Est Créteil, IMRB, Laboratory of Excellence LABEX GRex, Créteil, France.; Paris-East Créteil University, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Créteil, France., Six E; Laboratory of Human Lymphohematopoiesis, INSERM, Imagine Institute, Paris, France., Semeraro M; Centre d'Investigation Clinique-Unité de Recherche Clinique, Hôpital Universitaire Necker Enfants-Malades, GH Paris Centre, Paris, France.; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France., Miccio A; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France., Cavazzana M; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France. m.cavazzana@aphp.fr.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France. m.cavazzana@aphp.fr.
Source: Nature communications [Nat Commun] 2025 Apr 01; Vol. 16 (1), pp. 3137. Date of Electronic Publication: 2025 Apr 01.
Publication Type: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40169559
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Sobrino+S%22">Sobrino S</searchLink>; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France.; Laboratory of Human Lymphohematopoiesis, INSERM, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Joseph+L%22">Joseph L</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Magrin+E%22">Magrin E</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Chalumeau+A%22">Chalumeau A</searchLink>; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hebert+N%22">Hebert N</searchLink>; Univ Paris Est Créteil, IMRB, Laboratory of Excellence LABEX GRex, Créteil, France.; Etablissement Français du Sang, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Corsia+A%22">Corsia A</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France.<br /><searchLink fieldCode="AU" term="%22Denis+A%22">Denis A</searchLink>; Laboratory of Human Lymphohematopoiesis, INSERM, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Roudaut+C%22">Roudaut C</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Aussel+C%22">Aussel C</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Leblanc+O%22">Leblanc O</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Brusson+M%22">Brusson M</searchLink>; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Felix+T%22">Felix T</searchLink>; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Diana+JS%22">Diana JS</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Petrichenko+A%22">Petrichenko A</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22El+Etri+J%22">El Etri J</searchLink>; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France.; Laboratory of Human Lymphohematopoiesis, INSERM, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Godard+A%22">Godard A</searchLink>; Aix Marseille Univ, CNRS, EFS, ADES, Labex GR-Ex, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Tibi+E%22">Tibi E</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Manceau+S%22">Manceau S</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France.<br /><searchLink fieldCode="AU" term="%22Treluyer+JM%22">Treluyer JM</searchLink>; Centre d'Investigation Clinique-Unité de Recherche Clinique, Hôpital Universitaire Necker Enfants-Malades, GH Paris Centre, Paris, France.; Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mavilio+F%22">Mavilio F</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Bushman+FD%22">Bushman FD</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Marcais+A%22">Marcais A</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France.<br /><searchLink fieldCode="AU" term="%22Castelle+M%22">Castelle M</searchLink>; Pediatric Immunology and Hematology Department, Hôpital Necker Enfants-Malades, Paris, France.<br /><searchLink fieldCode="AU" term="%22Neven+B%22">Neven B</searchLink>; Pediatric Immunology and Hematology Department, Hôpital Necker Enfants-Malades, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hermine+O%22">Hermine O</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France.<br /><searchLink fieldCode="AU" term="%22Renolleau+S%22">Renolleau S</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Department of Adult Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Laboratory of Excellence LABEX GRex, Paris, France.<br /><searchLink fieldCode="AU" term="%22Magnani+A%22">Magnani A</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Asnafi+V%22">Asnafi V</searchLink>; Laboratory of Onco-Hematology, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.<br /><searchLink fieldCode="AU" term="%22El+Nemer+W%22">El Nemer W</searchLink>; Aix Marseille Univ, CNRS, EFS, ADES, Labex GR-Ex, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bartolucci+P%22">Bartolucci P</searchLink>; Univ Paris Est Créteil, IMRB, Laboratory of Excellence LABEX GRex, Créteil, France.; Paris-East Créteil University, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Six+E%22">Six E</searchLink>; Laboratory of Human Lymphohematopoiesis, INSERM, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Semeraro+M%22">Semeraro M</searchLink>; Centre d'Investigation Clinique-Unité de Recherche Clinique, Hôpital Universitaire Necker Enfants-Malades, GH Paris Centre, Paris, France.; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.<br /><searchLink fieldCode="AU" term="%22Miccio+A%22">Miccio A</searchLink>; Laboratory of Chromatin and Gene Regulation During Development, University Paris Cite, UMR1163 INSERM, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cavazzana+M%22">Cavazzana M</searchLink>; Departement of Biotherapy Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Universitaire Centre, Université Paris Cité, Paris, France. m.cavazzana@aphp.fr.; Biotherapy Clinical Investigation Center, AP-HP, INSERM, Institut Imagine, Paris, France. m.cavazzana@aphp.fr.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Apr 01; Vol. 16 (1), pp. 3137. <i>Date of Electronic Publication: </i>2025 Apr 01.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40169559
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-025-58321-4
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 3137
    Titles:
      – TitleFull: Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sobrino S
      – PersonEntity:
          Name:
            NameFull: Joseph L
      – PersonEntity:
          Name:
            NameFull: Magrin E
      – PersonEntity:
          Name:
            NameFull: Chalumeau A
      – PersonEntity:
          Name:
            NameFull: Hebert N
      – PersonEntity:
          Name:
            NameFull: Corsia A
      – PersonEntity:
          Name:
            NameFull: Denis A
      – PersonEntity:
          Name:
            NameFull: Roudaut C
      – PersonEntity:
          Name:
            NameFull: Aussel C
      – PersonEntity:
          Name:
            NameFull: Leblanc O
      – PersonEntity:
          Name:
            NameFull: Brusson M
      – PersonEntity:
          Name:
            NameFull: Felix T
      – PersonEntity:
          Name:
            NameFull: Diana JS
      – PersonEntity:
          Name:
            NameFull: Petrichenko A
      – PersonEntity:
          Name:
            NameFull: El Etri J
      – PersonEntity:
          Name:
            NameFull: Godard A
      – PersonEntity:
          Name:
            NameFull: Tibi E
      – PersonEntity:
          Name:
            NameFull: Manceau S
      – PersonEntity:
          Name:
            NameFull: Treluyer JM
      – PersonEntity:
          Name:
            NameFull: Mavilio F
      – PersonEntity:
          Name:
            NameFull: Bushman FD
      – PersonEntity:
          Name:
            NameFull: Marcais A
      – PersonEntity:
          Name:
            NameFull: Castelle M
      – PersonEntity:
          Name:
            NameFull: Neven B
      – PersonEntity:
          Name:
            NameFull: Hermine O
      – PersonEntity:
          Name:
            NameFull: Renolleau S
      – PersonEntity:
          Name:
            NameFull: Magnani A
      – PersonEntity:
          Name:
            NameFull: Asnafi V
      – PersonEntity:
          Name:
            NameFull: El Nemer W
      – PersonEntity:
          Name:
            NameFull: Bartolucci P
      – PersonEntity:
          Name:
            NameFull: Six E
      – PersonEntity:
          Name:
            NameFull: Semeraro M
      – PersonEntity:
          Name:
            NameFull: Miccio A
      – PersonEntity:
          Name:
            NameFull: Cavazzana M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2025 Apr 01
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1