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Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus.

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Title: Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus.
Authors: Klaver YLB; HollandPTC, Delft, The Netherlands; Department of Radiotherapy, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: y.klaver@hollandptc.nl., Hoogeman MS; HollandPTC, Delft, The Netherlands; Department of Radiotherapy, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Lu QR; Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Bradley JD; Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania., Choi JI; Department of Radiation Oncology, New York Proton Center, New York, New York; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., Ferris MJ; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland; Maryland Proton Treatment Center, Baltimore, Maryland., Grau C; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark., Guha C; Department of Radiation Oncology, Montefiore University Hospital, Bronx, New York., Lin H; Department of Radiation Oncology, New York Proton Center, New York, New York; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Radiation Oncology, Montefiore University Hospital, Bronx, New York., Lin L; Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia., Mascia AE; Cincinnati Children's Hospital Medical Center, Cancer and Blood Disease Institute, Division of Oncology, Cincinnati, Ohio., Moerman AM; HollandPTC, Delft, The Netherlands., Poulsen PR; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Shi LZ; Departments of Microbiology, Pharmacology & Toxicology; The Immunology Institute; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama., Singers Sørensen B; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Experimental Clinical Oncology, Aarhus University, Denmark., Tian S; Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia., Vozenin MC; Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland., Willey CD; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama., Zhou S; Radiation Oncology Department, University of Nebraska Medical Center, Omaha, Nebraska., Amos RA; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom., Hawkins M; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom; Clinical Oncology, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Simone CB 2nd; Department of Radiation Oncology, New York Proton Center, New York, New York; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Source: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2025 Sep 01; Vol. 123 (1), pp. 296-305. Date of Electronic Publication: 2025 Mar 31.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus.
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  Data: <searchLink fieldCode="AU" term="%22Klaver+YLB%22">Klaver YLB</searchLink>; HollandPTC, Delft, The Netherlands; Department of Radiotherapy, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: y.klaver@hollandptc.nl.<br /><searchLink fieldCode="AU" term="%22Hoogeman+MS%22">Hoogeman MS</searchLink>; HollandPTC, Delft, The Netherlands; Department of Radiotherapy, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lu+QR%22">Lu QR</searchLink>; Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Bradley+JD%22">Bradley JD</searchLink>; Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Choi+JI%22">Choi JI</searchLink>; Department of Radiation Oncology, New York Proton Center, New York, New York; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Ferris+MJ%22">Ferris MJ</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland; Maryland Proton Treatment Center, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Grau+C%22">Grau C</searchLink>; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Guha+C%22">Guha C</searchLink>; Department of Radiation Oncology, Montefiore University Hospital, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; Department of Radiation Oncology, New York Proton Center, New York, New York; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Radiation Oncology, Montefiore University Hospital, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Mascia+AE%22">Mascia AE</searchLink>; Cincinnati Children's Hospital Medical Center, Cancer and Blood Disease Institute, Division of Oncology, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Moerman+AM%22">Moerman AM</searchLink>; HollandPTC, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Poulsen+PR%22">Poulsen PR</searchLink>; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Shi+LZ%22">Shi LZ</searchLink>; Departments of Microbiology, Pharmacology & Toxicology; The Immunology Institute; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Singers+Sørensen+B%22">Singers Sørensen B</searchLink>; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Experimental Clinical Oncology, Aarhus University, Denmark.<br /><searchLink fieldCode="AU" term="%22Tian+S%22">Tian S</searchLink>; Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Vozenin+MC%22">Vozenin MC</searchLink>; Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Willey+CD%22">Willey CD</searchLink>; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Zhou+S%22">Zhou S</searchLink>; Radiation Oncology Department, University of Nebraska Medical Center, Omaha, Nebraska.<br /><searchLink fieldCode="AU" term="%22Amos+RA%22">Amos RA</searchLink>; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hawkins+M%22">Hawkins M</searchLink>; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom; Clinical Oncology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Simone+CB+2nd%22">Simone CB 2nd</searchLink>; Department of Radiation Oncology, New York Proton Center, New York, New York; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
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  Data: <searchLink fieldCode="JN" term="%227603616%22">International journal of radiation oncology, biology, physics</searchLink> [Int J Radiat Oncol Biol Phys] 2025 Sep 01; Vol. 123 (1), pp. 296-305. <i>Date of Electronic Publication: </i>2025 Mar 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+Inc%22">Elsevier, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7603616 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-355X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203603016%22">03603016 </searchLink><i>NLM ISO Abbreviation: </i>Int J Radiat Oncol Biol Phys <i>Subsets: </i>MEDLINE
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