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Efficacy and safety of allogeneic mesenchymal precursor cells with and without hyaluronic acid for treatment of chronic low back pain: a prospective, randomized, double blind, concurrent-controlled 36-month study.

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Title: Efficacy and safety of allogeneic mesenchymal precursor cells with and without hyaluronic acid for treatment of chronic low back pain: a prospective, randomized, double blind, concurrent-controlled 36-month study.
Authors: Beall DP; Comprehensive Specialty Care, 1023 Waterwood Pkwy, Edmond, OK, USA. Electronic address: db@clinrad.org., Bae HW; The Spine Institute, 2901 Wilshire Blvd. Suite 300, Santa Monica, CA, USA., DePalma MJ; Virginia Spine Research Institute, Inc., 12874 Patterson Avenue, Suite A, Richmond, VA, USA., Amirdelfan K; IPM Medical Group, Inc., 450 N. Wiget Lane, Walnut Creek, CA, USA., Tavel E; Clinical Trials of South Carolina, 2695 Elms Plantation Blvd. Suite D., Charleston, SC, USA., Davis TT; Source Healthcare, 2801 Wilshire Blvd, Suite A, Santa Monica, CA, USA., Bainbridge JS; The Denver Spine & Pain Institute, Greenwood Village, 7730 E Belleview Ave, Ste A200, CO, USA., Weil A; Nonsurgical Orthopedics, Coral Gables, 731 Almeria Ave., Coral Gables, USA., Beckworth W; Department of Orthopaedics, Emory University School of Medicine, 21 Ortho Lane, Atlanta, GA, USA., Kim K; University of California-Davis Neurological Surgery, Sacramento, 4860 Y Street, Suite 3740, CA, USA., Yuan P; Memorial Orthopaedic Surgical Group, Long Beach, 2760 Atlantic Ave., CA, USA., Gupta PB; Otrimed Clinical Research, Edgewood, 162 Barnwood Drive, KY, USA., Wang E; Summit Health, Garden City, 901 Franklin Ave, 2nd floor, NY, USA., Goodman BS; OrthoAlabama Spine & Sports, Birmingham, 1801 Gadsden Hwy, AL, USA., Reeves R; Spine Team Texas, Southlake, 1545 East Southlake Blvd, TX, USA., Furman MB; OSS Health and Temple University, 1861 Powder Mill Rd, PA, USA., Mekhail N; Cleveland Clinic, Cleveland, 9500 Euclid Ave, Ohio, USA., Nunez D; Mesoblast Inc., Bee Cave, 12912 Hill Country Blvd., Building F, Suite 230, TX, USA., DiMuro M; Mesoblast Inc., Bee Cave, 12912 Hill Country Blvd., Building F, Suite 230, TX, USA., Shonnard MC; Comprehensive Specialty Care, 1023 Waterwood Pkwy, Edmond, OK, USA., Rose E; Mesoblast Inc., Bee Cave, 12912 Hill Country Blvd., Building F, Suite 230, TX, USA., Brown RD; Mesoblast Inc., Bee Cave, 12912 Hill Country Blvd., Building F, Suite 230, TX, USA.
Source: The spine journal : official journal of the North American Spine Society [Spine J] 2025 Sep; Vol. 25 (9), pp. 1997-2013. Date of Electronic Publication: 2025 Mar 31.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 101130732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1632 (Electronic) Linking ISSN: 15299430 NLM ISO Abbreviation: Spine J Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Efficacy and safety of allogeneic mesenchymal precursor cells with and without hyaluronic acid for treatment of chronic low back pain: a prospective, randomized, double blind, concurrent-controlled 36-month study.
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  Data: <searchLink fieldCode="AU" term="%22Beall+DP%22">Beall DP</searchLink>; Comprehensive Specialty Care, 1023 Waterwood Pkwy, Edmond, OK, USA. Electronic address: db@clinrad.org.<br /><searchLink fieldCode="AU" term="%22Bae+HW%22">Bae HW</searchLink>; The Spine Institute, 2901 Wilshire Blvd. Suite 300, Santa Monica, CA, USA.<br /><searchLink fieldCode="AU" term="%22DePalma+MJ%22">DePalma MJ</searchLink>; Virginia Spine Research Institute, Inc., 12874 Patterson Avenue, Suite A, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Amirdelfan+K%22">Amirdelfan K</searchLink>; IPM Medical Group, Inc., 450 N. Wiget Lane, Walnut Creek, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tavel+E%22">Tavel E</searchLink>; Clinical Trials of South Carolina, 2695 Elms Plantation Blvd. Suite D., Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Davis+TT%22">Davis TT</searchLink>; Source Healthcare, 2801 Wilshire Blvd, Suite A, Santa Monica, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bainbridge+JS%22">Bainbridge JS</searchLink>; The Denver Spine & Pain Institute, Greenwood Village, 7730 E Belleview Ave, Ste A200, CO, USA.<br /><searchLink fieldCode="AU" term="%22Weil+A%22">Weil A</searchLink>; Nonsurgical Orthopedics, Coral Gables, 731 Almeria Ave., Coral Gables, USA.<br /><searchLink fieldCode="AU" term="%22Beckworth+W%22">Beckworth W</searchLink>; Department of Orthopaedics, Emory University School of Medicine, 21 Ortho Lane, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; University of California-Davis Neurological Surgery, Sacramento, 4860 Y Street, Suite 3740, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+P%22">Yuan P</searchLink>; Memorial Orthopaedic Surgical Group, Long Beach, 2760 Atlantic Ave., CA, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+PB%22">Gupta PB</searchLink>; Otrimed Clinical Research, Edgewood, 162 Barnwood Drive, KY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+E%22">Wang E</searchLink>; Summit Health, Garden City, 901 Franklin Ave, 2nd floor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Goodman+BS%22">Goodman BS</searchLink>; OrthoAlabama Spine & Sports, Birmingham, 1801 Gadsden Hwy, AL, USA.<br /><searchLink fieldCode="AU" term="%22Reeves+R%22">Reeves R</searchLink>; Spine Team Texas, Southlake, 1545 East Southlake Blvd, TX, USA.<br /><searchLink fieldCode="AU" term="%22Furman+MB%22">Furman MB</searchLink>; OSS Health and Temple University, 1861 Powder Mill Rd, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mekhail+N%22">Mekhail N</searchLink>; Cleveland Clinic, Cleveland, 9500 Euclid Ave, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Nunez+D%22">Nunez D</searchLink>; Mesoblast Inc., Bee Cave, 12912 Hill Country Blvd., Building F, Suite 230, TX, USA.<br /><searchLink fieldCode="AU" term="%22DiMuro+M%22">DiMuro M</searchLink>; Mesoblast Inc., Bee Cave, 12912 Hill Country Blvd., Building F, Suite 230, TX, USA.<br /><searchLink fieldCode="AU" term="%22Shonnard+MC%22">Shonnard MC</searchLink>; Comprehensive Specialty Care, 1023 Waterwood Pkwy, Edmond, OK, USA.<br /><searchLink fieldCode="AU" term="%22Rose+E%22">Rose E</searchLink>; Mesoblast Inc., Bee Cave, 12912 Hill Country Blvd., Building F, Suite 230, TX, USA.<br /><searchLink fieldCode="AU" term="%22Brown+RD%22">Brown RD</searchLink>; Mesoblast Inc., Bee Cave, 12912 Hill Country Blvd., Building F, Suite 230, TX, USA.
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  Data: <searchLink fieldCode="JN" term="%22101130732%22">The spine journal : official journal of the North American Spine Society</searchLink> [Spine J] 2025 Sep; Vol. 25 (9), pp. 1997-2013. <i>Date of Electronic Publication: </i>2025 Mar 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Inc%22">Elsevier Science Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130732 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-1632 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215299430%22">15299430 </searchLink><i>NLM ISO Abbreviation: </i>Spine J <i>Subsets: </i>MEDLINE
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        StartPage: 1997
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