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Random forest and Shapley Additive exPlanations predict oxytocin targeted effects on brain functional networks involved in salience and sensorimotor processing, in a randomized clinical trial in autism.

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Title: Random forest and Shapley Additive exPlanations predict oxytocin targeted effects on brain functional networks involved in salience and sensorimotor processing, in a randomized clinical trial in autism.
Authors: Andari E; Department of Neurosciences and Psychiatry, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA. eandari@gmail.com.; Adjunct Faculty in the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. eandari@gmail.com.; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA. eandari@gmail.com.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA. eandari@gmail.com., Gopinath K; Center for Systems Imaging Core, Department of Radiology and Imaging Sciences, G-131, Health Science Research Building II, Emory University, Atlanta, GA, 30322, USA., O'Leary E; Department of Neurosciences and Psychiatry, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.; The Max Harry Weil Institute, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA., Caceres GA; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Nishitani S; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.; Research Center for Child Mental Development, University of Fukui, Fukui, Japan., Smith AK; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA., Ousley O; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Rilling JK; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Department of Psychology, Emory University, Atlanta, GA, USA., Cubells JF; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Department of Human Genetics and Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Young LJ; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2025 Aug; Vol. 50 (9), pp. 1385-1394. Date of Electronic Publication: 2025 Apr 02.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
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  Data: Random forest and Shapley Additive exPlanations predict oxytocin targeted effects on brain functional networks involved in salience and sensorimotor processing, in a randomized clinical trial in autism.
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  Data: <searchLink fieldCode="AU" term="%22Andari+E%22">Andari E</searchLink>; Department of Neurosciences and Psychiatry, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA. eandari@gmail.com.; Adjunct Faculty in the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. eandari@gmail.com.; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA. eandari@gmail.com.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA. eandari@gmail.com.<br /><searchLink fieldCode="AU" term="%22Gopinath+K%22">Gopinath K</searchLink>; Center for Systems Imaging Core, Department of Radiology and Imaging Sciences, G-131, Health Science Research Building II, Emory University, Atlanta, GA, 30322, USA.<br /><searchLink fieldCode="AU" term="%22O'Leary+E%22">O'Leary E</searchLink>; Department of Neurosciences and Psychiatry, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.; The Max Harry Weil Institute, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Caceres+GA%22">Caceres GA</searchLink>; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Nishitani+S%22">Nishitani S</searchLink>; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.; Research Center for Child Mental Development, University of Fukui, Fukui, Japan.<br /><searchLink fieldCode="AU" term="%22Smith+AK%22">Smith AK</searchLink>; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ousley+O%22">Ousley O</searchLink>; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rilling+JK%22">Rilling JK</searchLink>; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Department of Psychology, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cubells+JF%22">Cubells JF</searchLink>; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Department of Human Genetics and Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Young+LJ%22">Young LJ</searchLink>; Center for Translational Social Neuroscience, Emory University School of Medicine, Atlanta, GA, USA.; Silivio O. Conte Center for Oxytocin and Social Cognition, Emory National Primate Research Center, Emory University, Atlanta, GA, 20329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
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