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Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.

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Title: Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
Authors: Dodean RA; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Li Y; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Zhang X; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Caridha D; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Madejczyk MS; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Jin X; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Dennis WE; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Chetree R; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Kudyba K; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., McEnearney S; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Lee PJ; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Blount C; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., DeLuca J; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Vuong C; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Pannone K; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Dinh HT; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Mdaki K; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Leed S; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Martin ML; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Pybus BS; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Pou S; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Winter RW; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Liebman KM; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Williams R; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Kumar A; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Chim-Ong A; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States., Cui L; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States., Orena S; Infectious Diseases Research Collaboration, Kampala, Uganda., Assimwe J; Infectious Diseases Research Collaboration, Kampala, Uganda., Tibagambirwa I; Infectious Diseases Research Collaboration, Kampala, Uganda., Byaruhanga O; Infectious Diseases Research Collaboration, Kampala, Uganda., Angutoko P; Infectious Diseases Research Collaboration, Kampala, Uganda., Legac J; Department of Medicine, University of California San Francisco, San Francisco, California 94143, United States., Kreutzfeld O; Department of Medicine, University of California San Francisco, San Francisco, California 94143, United States., Rosenthal PJ; Department of Medicine, University of California San Francisco, San Francisco, California 94143, United States., Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States., Nilsen A; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.; Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239, United States., Riscoe MK; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.; Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States., Roth A; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Kancharla P; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Kelly JX; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Apr 24; Vol. 68 (8), pp. 8817-8840. Date of Electronic Publication: 2025 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
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  Data: <searchLink fieldCode="AU" term="%22Dodean+RA%22">Dodean RA</searchLink>; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Caridha+D%22">Caridha D</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Madejczyk+MS%22">Madejczyk MS</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Jin+X%22">Jin X</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Dennis+WE%22">Dennis WE</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Chetree+R%22">Chetree R</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Kudyba+K%22">Kudyba K</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22McEnearney+S%22">McEnearney S</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Lee+PJ%22">Lee PJ</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Blount+C%22">Blount C</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22DeLuca+J%22">DeLuca J</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Vuong+C%22">Vuong C</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Pannone+K%22">Pannone K</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Dinh+HT%22">Dinh HT</searchLink>; 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Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Winter+RW%22">Winter RW</searchLink>; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Liebman+KM%22">Liebman KM</searchLink>; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Williams+R%22">Williams R</searchLink>; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.<br /><searchLink fieldCode="AU" term="%22Chim-Ong+A%22">Chim-Ong A</searchLink>; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.<br /><searchLink fieldCode="AU" term="%22Cui+L%22">Cui L</searchLink>; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.<br /><searchLink fieldCode="AU" term="%22Orena+S%22">Orena S</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Assimwe+J%22">Assimwe J</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Tibagambirwa+I%22">Tibagambirwa I</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Byaruhanga+O%22">Byaruhanga O</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Angutoko+P%22">Angutoko P</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Legac+J%22">Legac J</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, California 94143, United States.<br /><searchLink fieldCode="AU" term="%22Kreutzfeld+O%22">Kreutzfeld O</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, California 94143, United States.<br /><searchLink fieldCode="AU" term="%22Rosenthal+PJ%22">Rosenthal PJ</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, California 94143, United States.<br /><searchLink fieldCode="AU" term="%22Cooper+RA%22">Cooper RA</searchLink>; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.<br /><searchLink fieldCode="AU" term="%22Nilsen+A%22">Nilsen A</searchLink>; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.; Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Riscoe+MK%22">Riscoe MK</searchLink>; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.; Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Roth+A%22">Roth A</searchLink>; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Kancharla+P%22">Kancharla P</searchLink>; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+JX%22">Kelly JX</searchLink>; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
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