A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.
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| Title: | A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID. |
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| Authors: | M Bader S; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Calleja DJ; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Devine SM; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. devine.s@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, Australia. devine.s@wehi.edu.au., Kuchel NW; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Lu BGC; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Wu X; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Birkinshaw RW; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Bhandari R; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Loi K; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Volpe R; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Khakham Y; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Au AE; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Blackmore TR; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Mackiewicz L; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Dayton M; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Schaefer J; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Scherer L; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Stock AT; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Cooney JP; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Schoffer K; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Maluenda A; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Kleeman EA; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia., Davidson KC; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Allison CC; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Ebert G; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Katneni K; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Klemm TA; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Nachbur U; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Georgy SR; Anatomic Pathology - Veterinary Biosciences, Melbourne Veterinary School, University of Melbourne, Werribee, VIC, Australia., Czabotar PE; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Hannan AJ; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, Australia., Putoczki TL; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.; Department of Surgery, University of Melbourne, Melbourne, Australia., Tanzer M; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Pellegrini M; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.; Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, NSW, Australia., Lechtenberg BC; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Call MJ; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Mitchell JP; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Lowes KN; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Lessene G; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. glessene@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, Australia. glessene@wehi.edu.au.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Australia. glessene@wehi.edu.au., Doerflinger M; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. doerflinger.m@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, Australia. doerflinger.m@wehi.edu.au., Komander D; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. dk@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, Australia. dk@wehi.edu.au. |
| Source: | Nature communications [Nat Commun] 2025 Apr 03; Vol. 16 (1), pp. 2900. Date of Electronic Publication: 2025 Apr 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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