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Donor-derived CARCIK-CD19 cells engineered with Sleeping Beauty transposon in acute lymphoblastic leukemia relapsed after allogeneic transplantation.

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Title: Donor-derived CARCIK-CD19 cells engineered with Sleeping Beauty transposon in acute lymphoblastic leukemia relapsed after allogeneic transplantation.
Authors: Lussana F; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Department of Oncology and Hematology, University of Milan, Milan, Italy., Magnani CF; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Galimberti S; Department of Medicine and Surgery, Bicocca Bioinformatics, Biostatistics and Bioimaging Centre B4, University of Milano-Bicocca, Milan, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Gritti G; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Gaipa G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Belotti D; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Cabiati B; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Napolitano S; Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy., Ferrari S; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Moretti A; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy., Buracchi C; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Borleri GM; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Rambaldi B; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Rizzuto G; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Department of Oncology and Hematology, University of Milan, Milan, Italy., Grassi A; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Paganessi M; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Meli C; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Tettamanti S; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Risca G; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Pais G; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Spinozzi G; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Benedicenti F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Cazzaniga G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Capelli C; USS Centro di Terapia Cellulare 'G. Lanzani', Bergamo, Italy., Gotti E; USS Centro di Terapia Cellulare 'G. Lanzani', Bergamo, Italy., Introna M; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.; USS Centro di Terapia Cellulare 'G. Lanzani', Bergamo, Italy., Golay J; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.; USS Centro di Terapia Cellulare 'G. Lanzani', Bergamo, Italy., Montini E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Balduzzi A; Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy., Valsecchi MG; Department of Medicine and Surgery, Bicocca Bioinformatics, Biostatistics and Bioimaging Centre B4, University of Milano-Bicocca, Milan, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Dastoli G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Rambaldi A; Hematology and Bone Marrow Transplant Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Department of Oncology and Hematology, University of Milan, Milan, Italy., Biondi A; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. abiondi.unimib@gmail.com.; Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy. abiondi.unimib@gmail.com.
Source: Blood cancer journal [Blood Cancer J] 2025 Apr 03; Vol. 15 (1), pp. 54. Date of Electronic Publication: 2025 Apr 03.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2044-5385
DOI:10.1038/s41408-025-01260-6