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Severus detects somatic structural variation and complex rearrangements in cancer genomes using long-read sequencing.

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Title: Severus detects somatic structural variation and complex rearrangements in cancer genomes using long-read sequencing.
Authors: Keskus AG; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Bryant A; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Ahmad T; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Yoo B; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Aganezov S; Oxford Nanopore Technologies, New York, NY, USA., Goretsky A; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.; Department of Computer Science, University of Maryland, College Park, MD, USA., Donmez A; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.; Department of Computer Science, University of Maryland, College Park, MD, USA., Lansdon LA; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Rodriguez I; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Park J; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA., Liu Y; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.; Department of Computer Science, University of Maryland, College Park, MD, USA., Cui X; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Gardner J; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA., McNulty B; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA., Sacco S; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA., Shetty J; Sequencing Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Zhao Y; Sequencing Facility Bioinformatics Group, Biomedical Informatics and Data Science Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Tran B; Sequencing Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Narzisi G; New York Genome Center, New York, NY, USA., Helland A; New York Genome Center, New York, NY, USA., Cook DE; Google, Inc., Mountain View, CA, USA., Chang PC; Google, Inc., Mountain View, CA, USA., Kolesnikov A; Google, Inc., Mountain View, CA, USA., Carroll A; Google, Inc., Mountain View, CA, USA., Molloy EK; Department of Computer Science, University of Maryland, College Park, MD, USA., Bi C; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Walter A; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Gibson M; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Pushel I; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Guest E; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Pastinen T; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Shafin K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Miga KH; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA., Malikic S; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Day CP; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Robine N; New York Genome Center, New York, NY, USA., Sahinalp C; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Dean M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Farooqi MS; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Paten B; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA., Kolmogorov M; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. mikhail.kolmogorov@nih.gov.
Source: Nature biotechnology [Nat Biotechnol] 2026 Feb; Vol. 44 (2), pp. 247-257. Date of Electronic Publication: 2025 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: Severus detects somatic structural variation and complex rearrangements in cancer genomes using long-read sequencing.
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Department of Computer Science, University of Maryland, College Park, MD, USA.<br /><searchLink fieldCode="AU" term="%22Donmez+A%22">Donmez A</searchLink>; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.; Department of Computer Science, University of Maryland, College Park, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lansdon+LA%22">Lansdon LA</searchLink>; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+I%22">Rodriguez I</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.; 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Sequencing Facility Bioinformatics Group, Biomedical Informatics and Data Science Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tran+B%22">Tran B</searchLink>; Sequencing Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Narzisi+G%22">Narzisi G</searchLink>; New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Helland+A%22">Helland A</searchLink>; New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cook+DE%22">Cook DE</searchLink>; Google, Inc., Mountain View, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+PC%22">Chang PC</searchLink>; Google, Inc., Mountain View, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kolesnikov+A%22">Kolesnikov A</searchLink>; Google, Inc., Mountain View, CA, USA.<br /><searchLink fieldCode="AU" term="%22Carroll+A%22">Carroll A</searchLink>; Google, Inc., Mountain View, CA, USA.<br /><searchLink fieldCode="AU" term="%22Molloy+EK%22">Molloy EK</searchLink>; Department of Computer Science, University of Maryland, College Park, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bi+C%22">Bi C</searchLink>; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Walter+A%22">Walter A</searchLink>; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gibson+M%22">Gibson M</searchLink>; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Pushel+I%22">Pushel I</searchLink>; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Guest+E%22">Guest E</searchLink>; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Pastinen+T%22">Pastinen T</searchLink>; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Shafin+K%22">Shafin K</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Miga+KH%22">Miga KH</searchLink>; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Malikic+S%22">Malikic S</searchLink>; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Day+CP%22">Day CP</searchLink>; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Robine+N%22">Robine N</searchLink>; New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sahinalp+C%22">Sahinalp C</searchLink>; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dean+M%22">Dean M</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Farooqi+MS%22">Farooqi MS</searchLink>; Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Paten+B%22">Paten B</searchLink>; University of California, Santa Cruz, Genomics Institute, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kolmogorov+M%22">Kolmogorov M</searchLink>; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. mikhail.kolmogorov@nih.gov.
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