A novel physiologically-based pharmacokinetic model to estimate reduced CYP3A4 activity in cancer patients utilizing the neutrophil-to-lymphocyte ratio as an inflammatory marker.
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| Title: | A novel physiologically-based pharmacokinetic model to estimate reduced CYP3A4 activity in cancer patients utilizing the neutrophil-to-lymphocyte ratio as an inflammatory marker. |
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| Authors: | Coutant DE; Drug Disposition Department, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, DC0720 46285, USA. cout@lilly.com., Rehmel J; Global PK/PD and Pharmacometrics, Eli Lilly and Company, Indianapolis, Indiana, USA., Edwards DM; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA., Hall SD; Drug Disposition Department, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, DC0720 46285, USA. |
| Source: | European journal of clinical pharmacology [Eur J Clin Pharmacol] 2025 Jun; Vol. 81 (6), pp. 853-862. Date of Electronic Publication: 2025 Apr 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Germany NLM ID: 1256165 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1041 (Electronic) Linking ISSN: 00316970 NLM ISO Abbreviation: Eur J Clin Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40186675 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A novel physiologically-based pharmacokinetic model to estimate reduced CYP3A4 activity in cancer patients utilizing the neutrophil-to-lymphocyte ratio as an inflammatory marker. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Coutant+DE%22">Coutant DE</searchLink>; Drug Disposition Department, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, DC0720 46285, USA. cout@lilly.com.<br /><searchLink fieldCode="AU" term="%22Rehmel+J%22">Rehmel J</searchLink>; Global PK/PD and Pharmacometrics, Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+DM%22">Edwards DM</searchLink>; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Hall+SD%22">Hall SD</searchLink>; Drug Disposition Department, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, DC0720 46285, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%221256165%22">European journal of clinical pharmacology</searchLink> [Eur J Clin Pharmacol] 2025 Jun; Vol. 81 (6), pp. 853-862. <i>Date of Electronic Publication: </i>2025 Apr 05. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>1256165 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1041 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200316970%22">00316970 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Clin Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40186675 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00228-025-03839-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 853 Titles: – TitleFull: A novel physiologically-based pharmacokinetic model to estimate reduced CYP3A4 activity in cancer patients utilizing the neutrophil-to-lymphocyte ratio as an inflammatory marker. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Coutant DE – PersonEntity: Name: NameFull: Rehmel J – PersonEntity: Name: NameFull: Edwards DM – PersonEntity: Name: NameFull: Hall SD IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2025 Jun Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1432-1041 Numbering: – Type: volume Value: 81 – Type: issue Value: 6 Titles: – TitleFull: European journal of clinical pharmacology Type: main |
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