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Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery.

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Title: Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery.
Authors: Petrov D; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland., Plais L; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland., Schira K; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland., Cai J; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland., Keller M; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland., Lessing A; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland., Bassi G; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland., Cazzamalli S; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland., Neri D; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland., Gloger A; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland., Scheuermann J; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland. joerg.scheuermann@pharma.ethz.ch.
Source: Nature communications [Nat Commun] 2025 Apr 05; Vol. 16 (1), pp. 3273. Date of Electronic Publication: 2025 Apr 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Petrov+D%22">Petrov D</searchLink>; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Plais+L%22">Plais L</searchLink>; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schira+K%22">Schira K</searchLink>; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cai+J%22">Cai J</searchLink>; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Keller+M%22">Keller M</searchLink>; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lessing+A%22">Lessing A</searchLink>; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bassi+G%22">Bassi G</searchLink>; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cazzamalli+S%22">Cazzamalli S</searchLink>; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Neri+D%22">Neri D</searchLink>; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gloger+A%22">Gloger A</searchLink>; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Scheuermann+J%22">Scheuermann J</searchLink>; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland. joerg.scheuermann@pharma.ethz.ch.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Apr 05; Vol. 16 (1), pp. 3273. <i>Date of Electronic Publication: </i>2025 Apr 05.
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