Potassium-competitive acid blocker vs proton-pump inhibitor in patients receiving antithrombotic therapy who are at high risk for gastrointestinal bleeding: Rationale and design of the randomized PROTECT- HBR trial.

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Title: Potassium-competitive acid blocker vs proton-pump inhibitor in patients receiving antithrombotic therapy who are at high risk for gastrointestinal bleeding: Rationale and design of the randomized PROTECT- HBR trial.
Authors: Lee J; Division of Cardiology, Kyung Hee Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea., Park HS; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Lee J; Department of Cardiology, Eunpyeong St. Mary's Hospital, Seoul, South Korea., Choi KD; Division of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Kang DY; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Ahn JM; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Kim W; Division of Cardiology, Kyung Hee Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea., Lee JY; Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea., Lim YH; Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, South Korea., Kang SH; Department of Cardiology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea., Kwon SU; Department of Cardiology, Ilsan-Paik Hospital, Inje University College of Medicine, Goyang, South Korea., Park H; Division of Cardiology, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea., Choi EK; Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea., Hong SJ; Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea., Kim BK; Division of Cardiology, Severance Cardiovascular Hospital. Yonsei University College of Medicine, Seoul., Jin ES; Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea., Jeong JO; Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, South Korea., Nam CW; Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Keimyung University Dongsan Hospital, Keimyung University College of Medicine, Daegu, South Korea., Lee WS; Division of Cardiology, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, South Korea., Kim SM; Regional Cardiovascular Center, Division of Cardiology, Chungbuk National University Hospital, Cheongju, South Korea., Park KH; Division of Cardiovascular Disease, Hallym University Medical Center, Anyang, South Korea., Her SH; Department of Cardiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea., Shin ES; Division of Cardiology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea., Choi YJ; Department of Cardiology, Sejong General Hospital, Bucheon, South Korea., Yang TH; Department of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, South Korea., Kim SH; Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea., Suh JW; Department of Cardiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea., Park HC; Division of Cardiology, Department of Internal Medicine, Hanyang University Guri Hospital, Guri, South Korea., Yoon YH; Department of Cardiology, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, Sejong, South Korea., Yoon MH; Department of Cardiology, Ajou University School of Medicine, Suwon, South Korea., Park SJ; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Park DW; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address: dwpark@amc.seoul.kr.
Corporate Authors: PROTECT-HBR Trial
Source: American heart journal [Am Heart J] 2025 Sep; Vol. 287, pp. 50-60. Date of Electronic Publication: 2025 Apr 04.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Potassium-competitive acid blocker vs proton-pump inhibitor in patients receiving antithrombotic therapy who are at high risk for gastrointestinal bleeding: Rationale and design of the randomized PROTECT- HBR trial.
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  Data: <searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Division of Cardiology, Kyung Hee Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+HS%22">Park HS</searchLink>; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Cardiology, Eunpyeong St. Mary's Hospital, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Choi+KD%22">Choi KD</searchLink>; Division of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kang+DY%22">Kang DY</searchLink>; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Ahn+JM%22">Ahn JM</searchLink>; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+W%22">Kim W</searchLink>; Division of Cardiology, Kyung Hee Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lim+YH%22">Lim YH</searchLink>; Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kang+SH%22">Kang SH</searchLink>; Department of Cardiology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+SU%22">Kwon SU</searchLink>; Department of Cardiology, Ilsan-Paik Hospital, Inje University College of Medicine, Goyang, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+H%22">Park H</searchLink>; Division of Cardiology, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea.<br /><searchLink fieldCode="AU" term="%22Choi+EK%22">Choi EK</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Hong+SJ%22">Hong SJ</searchLink>; Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+BK%22">Kim BK</searchLink>; Division of Cardiology, Severance Cardiovascular Hospital. Yonsei University College of Medicine, Seoul.<br /><searchLink fieldCode="AU" term="%22Jin+ES%22">Jin ES</searchLink>; Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+JO%22">Jeong JO</searchLink>; Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, South Korea.<br /><searchLink fieldCode="AU" term="%22Nam+CW%22">Nam CW</searchLink>; Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Keimyung University Dongsan Hospital, Keimyung University College of Medicine, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+WS%22">Lee WS</searchLink>; Division of Cardiology, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SM%22">Kim SM</searchLink>; Regional Cardiovascular Center, Division of Cardiology, Chungbuk National University Hospital, Cheongju, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+KH%22">Park KH</searchLink>; Division of Cardiovascular Disease, Hallym University Medical Center, Anyang, South Korea.<br /><searchLink fieldCode="AU" term="%22Her+SH%22">Her SH</searchLink>; Department of Cardiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea.<br /><searchLink fieldCode="AU" term="%22Shin+ES%22">Shin ES</searchLink>; Division of Cardiology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Choi+YJ%22">Choi YJ</searchLink>; Department of Cardiology, Sejong General Hospital, Bucheon, South Korea.<br /><searchLink fieldCode="AU" term="%22Yang+TH%22">Yang TH</searchLink>; Department of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Suh+JW%22">Suh JW</searchLink>; Department of Cardiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+HC%22">Park HC</searchLink>; Division of Cardiology, Department of Internal Medicine, Hanyang University Guri Hospital, Guri, South Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+YH%22">Yoon YH</searchLink>; Department of Cardiology, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, Sejong, South Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+MH%22">Yoon MH</searchLink>; Department of Cardiology, Ajou University School of Medicine, Suwon, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+SJ%22">Park SJ</searchLink>; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+DW%22">Park DW</searchLink>; Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address: dwpark@amc.seoul.kr.
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  Data: <searchLink fieldCode="JN" term="%220370465%22">American heart journal</searchLink> [Am Heart J] 2025 Sep; Vol. 287, pp. 50-60. <i>Date of Electronic Publication: </i>2025 Apr 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370465 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-6744 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200028703%22">00028703 </searchLink><i>NLM ISO Abbreviation: </i>Am Heart J <i>Subsets: </i>MEDLINE
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