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Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas.

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Title: Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas.
Authors: Li Y; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Cui Z; Department of Dermatology and Venereology, Peking University First Hospital, Peking University, Beijing, China., Song X; ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.; Mucosal Melanoma Diagnosis and Treatment Center, Eye & ENT Hospital, Fudan University, Shanghai, China., Chen Y; Department of Computer Science, Ying Wu College of Computing, New Jersey Institute of Technology, Newark, New Jersey., Li C; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Shi J; ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China., Qian W; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang., Ren G; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Zhou J; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Li C; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Ma X; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Chen Y; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Jia D; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang., Zhang Y; School of Life Science, Beijing University of Chinese Medicine, Beijing, China., Zhang Z; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhang R; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhang Z; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Chen Y; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Shanghai, China., Xu Z; School of Life Sciences, Henan University, Kaifeng, China., Chen W; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Miao X; Department of Dermatology, Shuguang Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Yu H; ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.; Research Unit of New Technologies of Endoscopic Surgery In Skull Base Tumor(2018RU003), Chinese Academy of Medical Sciences, Beijing, China., Chen J; School of Life Science, Beijing University of Chinese Medicine, Beijing, China., Wang K; Department of Respiratory and Critical Care Medicine, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China., Goding CR; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Wei Z; Department of Computer Science, Ying Wu College of Computing, New Jersey Institute of Technology, Newark, New Jersey., Li T; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang., Cui R; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 Jun 13; Vol. 31 (12), pp. 2495-2514.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas.
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cui+Z%22">Cui Z</searchLink>; Department of Dermatology and Venereology, Peking University First Hospital, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Song+X%22">Song X</searchLink>; ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.; Mucosal Melanoma Diagnosis and Treatment Center, Eye & ENT Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Computer Science, Ying Wu College of Computing, New Jersey Institute of Technology, Newark, New Jersey.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Qian+W%22">Qian W</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang.<br /><searchLink fieldCode="AU" term="%22Ren+G%22">Ren G</searchLink>; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Jia+D%22">Jia D</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; School of Life Science, Beijing University of Chinese Medicine, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; School of Life Sciences, Henan University, Kaifeng, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Miao+X%22">Miao X</searchLink>; Department of Dermatology, Shuguang Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.; Research Unit of New Technologies of Endoscopic Surgery In Skull Base Tumor(2018RU003), Chinese Academy of Medical Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; School of Life Science, Beijing University of Chinese Medicine, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Department of Respiratory and Critical Care Medicine, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.<br /><searchLink fieldCode="AU" term="%22Goding+CR%22">Goding CR</searchLink>; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wei+Z%22">Wei Z</searchLink>; Department of Computer Science, Ying Wu College of Computing, New Jersey Institute of Technology, Newark, New Jersey.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang.<br /><searchLink fieldCode="AU" term="%22Cui+R%22">Cui R</searchLink>; Skin Disease Research Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Zhejiang Provincial Clinical Research Center for CANCER, Cancer Center of Zhejiang University, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
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