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APOE Haplotype Phasing Using ONT Long-Read Sequencing Reveals Two Common ε3 and ε4 intragenic haplotypes in the Spanish Population.

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Title: APOE Haplotype Phasing Using ONT Long-Read Sequencing Reveals Two Common ε3 and ε4 intragenic haplotypes in the Spanish Population.
Authors: García-González P; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; PhD program in Biotecnology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028- Barcelona, Spain., Puerta R; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; PhD program in Biotecnology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028- Barcelona, Spain., Cano A; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Olivè C; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain., Marquié M; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Valero S; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Rosende-Roca M; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alegret M; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Sanz P; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain., Brosseron F; Universitätsklinikum Bonn & Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Bonn, Germany., Martino-Adami P; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany., de Rojas I; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Eschsur-Alzette/Belvaux, Luxembourg., Heneka M; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Eschsur-Alzette/Belvaux, Luxembourg., Ramírez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, 53127 Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Department of Psychiatry and Glenn, Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San An TX USA., Navarro A; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra. Pg. Lluís Companys 23, 08010, Barcelona, Spain.; IBE, Institute of Evolutionary Biology (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra. PRBB, C. Doctor Aiguader N88, 08003 Barcelona, Spain.; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Av. Doctor Aiguader, N88, 08003 Barcelona, Spain.; BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, C. Wellington 30, 08005, Barcelona, Spain., Sáez ME; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Tárraga L; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Cavazos JE; South Texas Medical Science Training Program, University of Texas Health San Antonio, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA., Boada M; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Fernandez MV; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain., Cabrera-Socorro A; Janssen Pharmaceutica NV, a Johnson & Johnson company, Beerse, Belgium., Ruiz A; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Microbiology, Immunology and Molecular Genetics. Long School of Medicine. University of Texas Health Science Center, San Antonio, TX, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Mar 25. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: APOE Haplotype Phasing Using ONT Long-Read Sequencing Reveals Two Common ε3 and ε4 intragenic haplotypes in the Spanish Population.
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  Data: <searchLink fieldCode="AU" term="%22García-González+P%22">García-González P</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; PhD program in Biotecnology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028- Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Puerta+R%22">Puerta R</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; PhD program in Biotecnology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028- Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cano+A%22">Cano A</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Olivè+C%22">Olivè C</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Marquié+M%22">Marquié M</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Valero+S%22">Valero S</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rosende-Roca+M%22">Rosende-Roca M</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alegret+M%22">Alegret M</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+P%22">Sanz P</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Brosseron+F%22">Brosseron F</searchLink>; Universitätsklinikum Bonn & Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Martino-Adami+P%22">Martino-Adami P</searchLink>; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22de+Rojas+I%22">de Rojas I</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Eschsur-Alzette/Belvaux, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Heneka+M%22">Heneka M</searchLink>; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Eschsur-Alzette/Belvaux, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Ramírez+A%22">Ramírez A</searchLink>; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, 53127 Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Department of Psychiatry and Glenn, Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San An TX USA.<br /><searchLink fieldCode="AU" term="%22Navarro+A%22">Navarro A</searchLink>; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra. Pg. Lluís Companys 23, 08010, Barcelona, Spain.; IBE, Institute of Evolutionary Biology (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra. PRBB, C. Doctor Aiguader N88, 08003 Barcelona, Spain.; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Av. Doctor Aiguader, N88, 08003 Barcelona, Spain.; BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, C. Wellington 30, 08005, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sáez+ME%22">Sáez ME</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Tárraga+L%22">Tárraga L</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cavazos+JE%22">Cavazos JE</searchLink>; South Texas Medical Science Training Program, University of Texas Health San Antonio, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Boada+M%22">Boada M</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez+MV%22">Fernandez MV</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cabrera-Socorro+A%22">Cabrera-Socorro A</searchLink>; Janssen Pharmaceutica NV, a Johnson & Johnson company, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Ruiz+A%22">Ruiz A</searchLink>; ACE Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Microbiology, Immunology and Molecular Genetics. Long School of Medicine. University of Texas Health Science Center, San Antonio, TX, USA.
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