High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

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Title: High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.
Authors: Yang D; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Department of Physical and Environmental Sciences, University of Toronto, Toronto, ON, Canada., Wang X; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Liu J; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada., Gong Y; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Nair P; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Sun J; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Qian X; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Cui C; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Zeng H; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Dong A; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Harding RJ; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Burgess-Brown N; Structural Genomics Consortium, University College London, London, United Kingdom., Beyett TS; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, United States., Song D; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Krause H; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada., Diamond ML; School of the Environment, University of Toronto, Toronto, ON, Canada.; Department of Earth Sciences, University of Toronto, Toronto, ON, Canada., Bolhuis DL; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Brown NG; Pharmacology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Edwards AM; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Peng H; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; School of the Environment, University of Toronto, Toronto, ON, Canada.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Mar 25. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.03.20.644436