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High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

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Title: High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.
Authors: Yang D; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Department of Physical and Environmental Sciences, University of Toronto, Toronto, ON, Canada., Wang X; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Liu J; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada., Gong Y; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Nair P; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Sun J; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Qian X; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Cui C; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Zeng H; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Dong A; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Harding RJ; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Burgess-Brown N; Structural Genomics Consortium, University College London, London, United Kingdom., Beyett TS; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, United States., Song D; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Krause H; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada., Diamond ML; School of the Environment, University of Toronto, Toronto, ON, Canada.; Department of Earth Sciences, University of Toronto, Toronto, ON, Canada., Bolhuis DL; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Brown NG; Pharmacology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Edwards AM; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Peng H; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; School of the Environment, University of Toronto, Toronto, ON, Canada.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Mar 25. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.
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  Data: <searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Department of Physical and Environmental Sciences, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gong+Y%22">Gong Y</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Nair+P%22">Nair P</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Qian+X%22">Qian X</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cui+C%22">Cui C</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dong+A%22">Dong A</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Harding+RJ%22">Harding RJ</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Burgess-Brown+N%22">Burgess-Brown N</searchLink>; Structural Genomics Consortium, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Beyett+TS%22">Beyett TS</searchLink>; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, United States.<br /><searchLink fieldCode="AU" term="%22Song+D%22">Song D</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Krause+H%22">Krause H</searchLink>; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Diamond+ML%22">Diamond ML</searchLink>; School of the Environment, University of Toronto, Toronto, ON, Canada.; Department of Earth Sciences, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bolhuis+DL%22">Bolhuis DL</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.<br /><searchLink fieldCode="AU" term="%22Brown+NG%22">Brown NG</searchLink>; Pharmacology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.<br /><searchLink fieldCode="AU" term="%22Arrowsmith+CH%22">Arrowsmith CH</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Edwards+AM%22">Edwards AM</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Halabelian+L%22">Halabelian L</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Peng+H%22">Peng H</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; School of the Environment, University of Toronto, Toronto, ON, Canada.
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