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Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence.

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Title: Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence.
Authors: Lu J; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Rao SR; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Knowles H; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Zhan H; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Gamez B; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Platt E; Medicines Discovery Catapult, Cheshire, UK., Frost LR; Medicines Discovery Catapult, Cheshire, UK., Allen TJ; Medicines Discovery Catapult, Cheshire, UK., Marshall G; Medicines Discovery Catapult, Cheshire, UK., Huber KVM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bauer LG; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Vendrell I; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kessler B; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Horne A; Faculty of Medical and Health Sciences, University of Auckland, Auckland, NZ., Reid IR; Faculty of Medical and Health Sciences, University of Auckland, Auckland, NZ., Bountra C; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kirkland JL; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, USA., Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Hal Ebetino F; BioVinc LLC, Pasadena, CA, US; Chemistry Dept, University of Rochester, Rochester, NY, USA., Roldan E; Qualix DoT, Barcelona, Spain., Russell RGG; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Mellanby Centre for Bone Research, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield Medical School, Sheffield, UK., Edwards JR; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Mar 26. Date of Electronic Publication: 2025 Mar 26.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence.
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  Data: <searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rao+SR%22">Rao SR</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Knowles+H%22">Knowles H</searchLink>; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Zhan+H%22">Zhan H</searchLink>; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gamez+B%22">Gamez B</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Platt+E%22">Platt E</searchLink>; Medicines Discovery Catapult, Cheshire, UK.<br /><searchLink fieldCode="AU" term="%22Frost+LR%22">Frost LR</searchLink>; Medicines Discovery Catapult, Cheshire, UK.<br /><searchLink fieldCode="AU" term="%22Allen+TJ%22">Allen TJ</searchLink>; Medicines Discovery Catapult, Cheshire, UK.<br /><searchLink fieldCode="AU" term="%22Marshall+G%22">Marshall G</searchLink>; Medicines Discovery Catapult, Cheshire, UK.<br /><searchLink fieldCode="AU" term="%22Huber+KVM%22">Huber KVM</searchLink>; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bauer+LG%22">Bauer LG</searchLink>; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Vendrell+I%22">Vendrell I</searchLink>; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kessler+B%22">Kessler B</searchLink>; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Horne+A%22">Horne A</searchLink>; Faculty of Medical and Health Sciences, University of Auckland, Auckland, NZ.<br /><searchLink fieldCode="AU" term="%22Reid+IR%22">Reid IR</searchLink>; Faculty of Medical and Health Sciences, University of Auckland, Auckland, NZ.<br /><searchLink fieldCode="AU" term="%22Bountra+C%22">Bountra C</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, USA.<br /><searchLink fieldCode="AU" term="%22Khosla+S%22">Khosla S</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hal+Ebetino+F%22">Hal Ebetino F</searchLink>; BioVinc LLC, Pasadena, CA, US; Chemistry Dept, University of Rochester, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Roldan+E%22">Roldan E</searchLink>; Qualix DoT, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Russell+RGG%22">Russell RGG</searchLink>; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Mellanby Centre for Bone Research, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield Medical School, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+JR%22">Edwards JR</searchLink>; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
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