A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature.

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Title: A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature.
Authors: Marshe VS; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Tuddenham JF; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, USA.; Icahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, 10029, USA.; Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, 10029, USA., Chen K; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Chiu R; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Haage VC; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Ma Y; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Lee AJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA., Shneider NA; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Eleanor and Lou Gehrig ALS Center, Columbia University Medical Center, New York, NY, USA., Agin-Liebes JP; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Alcalay RN; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Movement Disorders Division, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Teich AF; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA., Riley CS; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Keene D; Department of Laboratory Medicine and Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, USA., Menon V; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Taga M; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Klein HU; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Olah M; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Fujita M; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Zhang Y; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, USA.; Dept. of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, USA.; Chan Zuckerberg Biohub, New York, New York, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Mar 28. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.03.27.641500