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A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature.

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Title: A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature.
Authors: Marshe VS; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Tuddenham JF; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, USA.; Icahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, 10029, USA.; Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, 10029, USA., Chen K; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Chiu R; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Haage VC; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Ma Y; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Lee AJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA., Shneider NA; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Eleanor and Lou Gehrig ALS Center, Columbia University Medical Center, New York, NY, USA., Agin-Liebes JP; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Alcalay RN; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Movement Disorders Division, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Teich AF; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA., Riley CS; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Keene D; Department of Laboratory Medicine and Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, USA., Menon V; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Taga M; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Klein HU; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Olah M; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Fujita M; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Zhang Y; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, USA.; Dept. of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, USA.; Chan Zuckerberg Biohub, New York, New York, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Mar 28. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature.
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  Data: <searchLink fieldCode="AU" term="%22Marshe+VS%22">Marshe VS</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Tuddenham+JF%22">Tuddenham JF</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, USA.; Icahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, 10029, USA.; Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Chiu+R%22">Chiu R</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Haage+VC%22">Haage VC</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lee+AJ%22">Lee AJ</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Shneider+NA%22">Shneider NA</searchLink>; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Eleanor and Lou Gehrig ALS Center, Columbia University Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Agin-Liebes+JP%22">Agin-Liebes JP</searchLink>; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alcalay+RN%22">Alcalay RN</searchLink>; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Movement Disorders Division, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Teich+AF%22">Teich AF</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Canoll+P%22">Canoll P</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Riley+CS%22">Riley CS</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Keene+D%22">Keene D</searchLink>; Department of Laboratory Medicine and Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+JA%22">Schneider JA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, USA.<br /><searchLink fieldCode="AU" term="%22Menon+V%22">Menon V</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Taga+M%22">Taga M</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Klein+HU%22">Klein HU</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Olah+M%22">Olah M</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fujita+M%22">Fujita M</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Sims+PA%22">Sims PA</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, USA.; Dept. of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, USA.; Chan Zuckerberg Biohub, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Mar 28. <i>Date of Electronic Publication: </i>2025 Mar 28.
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        Value: 10.1101/2025.03.27.641500
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