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Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells.

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Title: Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells.
Authors: Rueger S; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.; German Centre for Infection Research (DZIF), partner site Munich, Germany., Gruener E; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany., Wang D; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Abdool FS; Africa Health Research Institute (AHRI), and.; Department of Laboratory Medicine and Medical Science, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal (UKZN), Durban, South Africa., Ober V; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany., Vallée T; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, and., Stirner R; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany., Conca R; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany., Andrä I; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany., Rogers L; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Zahn R; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany., Gersbacher E; MUC Research, Clinical Research, Munich, Germany., Eger J; Zentrum fuer Innere Medizin und Infektiologie, Munich, Germany., Pauli R; MVZ am Isartor, Munich, Germany., Postel N; prinzmed, Practice for Infectiology, Munich, Germany., Spinner CD; TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, University Medical Center, Technical University of Munich, Munich, Germany., Vehreschild JJ; Medical Department 2, Hematology/Oncology and Infectious Diseases, University Hospital of Frankfurt, Frankfurt, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, Cologne, Germany.; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Germany., Stecher M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, Cologne, Germany.; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Germany., Nitschko H; Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, and., Eberle J; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, and., Bogner JR; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.; German Centre for Infection Research (DZIF), partner site Munich, Germany., Seybold U; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany., Draenert R; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.; Antibiotic Stewardship Team, LMU University Hospital, LMU Munich, Munich, Germany., Leslie A; Africa Health Research Institute (AHRI), and.; Department of Infection and Immunity, University College London (UCL), London, United Kingdom., Kløverpris HN; Africa Health Research Institute (AHRI), and.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Geldmacher C; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany., Muenchhoff M; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, and., Held K; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Neuherberg, Germany., Roider J; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.; German Centre for Infection Research (DZIF), partner site Munich, Germany.
Source: JCI insight [JCI Insight] 2025 Apr 08; Vol. 10 (7). Date of Electronic Publication: 2025 Apr 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
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  Data: Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells.
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  Data: <searchLink fieldCode="AU" term="%22Rueger+S%22">Rueger S</searchLink>; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.; German Centre for Infection Research (DZIF), partner site Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gruener+E%22">Gruener E</searchLink>; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Abdool+FS%22">Abdool FS</searchLink>; Africa Health Research Institute (AHRI), and.; Department of Laboratory Medicine and Medical Science, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal (UKZN), Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Ober+V%22">Ober V</searchLink>; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vallée+T%22">Vallée T</searchLink>; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, and.<br /><searchLink fieldCode="AU" term="%22Stirner+R%22">Stirner R</searchLink>; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Conca+R%22">Conca R</searchLink>; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Andrä+I%22">Andrä I</searchLink>; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rogers+L%22">Rogers L</searchLink>; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zahn+R%22">Zahn R</searchLink>; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gersbacher+E%22">Gersbacher E</searchLink>; MUC Research, Clinical Research, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Eger+J%22">Eger J</searchLink>; Zentrum fuer Innere Medizin und Infektiologie, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pauli+R%22">Pauli R</searchLink>; MVZ am Isartor, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Postel+N%22">Postel N</searchLink>; prinzmed, Practice for Infectiology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Spinner+CD%22">Spinner CD</searchLink>; TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, University Medical Center, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vehreschild+JJ%22">Vehreschild JJ</searchLink>; Medical Department 2, Hematology/Oncology and Infectious Diseases, University Hospital of Frankfurt, Frankfurt, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, Cologne, Germany.; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Stecher+M%22">Stecher M</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, Cologne, Germany.; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Nitschko+H%22">Nitschko H</searchLink>; Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, and.<br /><searchLink fieldCode="AU" term="%22Eberle+J%22">Eberle J</searchLink>; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, and.<br /><searchLink fieldCode="AU" term="%22Bogner+JR%22">Bogner JR</searchLink>; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.; German Centre for Infection Research (DZIF), partner site Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Seybold+U%22">Seybold U</searchLink>; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Draenert+R%22">Draenert R</searchLink>; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.; Antibiotic Stewardship Team, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Leslie+A%22">Leslie A</searchLink>; Africa Health Research Institute (AHRI), and.; Department of Infection and Immunity, University College London (UCL), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kløverpris+HN%22">Kløverpris HN</searchLink>; Africa Health Research Institute (AHRI), and.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Geldmacher+C%22">Geldmacher C</searchLink>; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Muenchhoff+M%22">Muenchhoff M</searchLink>; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, and.<br /><searchLink fieldCode="AU" term="%22Held+K%22">Held K</searchLink>; German Centre for Infection Research (DZIF), partner site Munich, Germany.; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Roider+J%22">Roider J</searchLink>; Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.; German Centre for Infection Research (DZIF), partner site Munich, Germany.
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