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Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma.

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Title: Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma.
Authors: Arnold MR; Medical Scientist Training Program, Oregon Health and Science University, Portland, OR, USA.; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA., Cohn GM; Department of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR, USA., Oxe KC; Danish Cancer Institute, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark., Elliott SN; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA., Moore C; Research Services, Neurocytology Laboratory, Veterans Affairs Medical Center, Portland, OR, USA., Zhou AM; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA., Laraia PV; Independent researcher, San Mateo, California, USA., Shekoohi S; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA., Brownell D; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA., Sears RC; Department of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Woltjer RL; Layton Aging & Alzheimer's Disease Research Center and Department of Pathology, Oregon Health and Science University, Portland, OR, USA., Meshul CK; Research Services, Neurocytology Laboratory, Veterans Affairs Medical Center, Portland, OR, USA.; Departments of Behavioral Neuroscience and Pathology, Oregon Health and Science University, Portland, OR, USA., Witt SN; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.; Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, USA., Larsen DH; Danish Cancer Institute, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark., Unni VK; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA.; OHSU Parkinson Center, Oregon Health and Science University, Portland, OR, USA.
Source: Science advances [Sci Adv] 2025 Apr 11; Vol. 11 (15), pp. eadq2519. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Arnold+MR%22">Arnold MR</searchLink>; Medical Scientist Training Program, Oregon Health and Science University, Portland, OR, USA.; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Cohn+GM%22">Cohn GM</searchLink>; Department of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Oxe+KC%22">Oxe KC</searchLink>; Danish Cancer Institute, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Elliott+SN%22">Elliott SN</searchLink>; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Moore+C%22">Moore C</searchLink>; Research Services, Neurocytology Laboratory, Veterans Affairs Medical Center, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+AM%22">Zhou AM</searchLink>; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Laraia+PV%22">Laraia PV</searchLink>; Independent researcher, San Mateo, California, USA.<br /><searchLink fieldCode="AU" term="%22Shekoohi+S%22">Shekoohi S</searchLink>; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Brownell+D%22">Brownell D</searchLink>; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Sears+RC%22">Sears RC</searchLink>; Department of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Woltjer+RL%22">Woltjer RL</searchLink>; Layton Aging & Alzheimer's Disease Research Center and Department of Pathology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Meshul+CK%22">Meshul CK</searchLink>; Research Services, Neurocytology Laboratory, Veterans Affairs Medical Center, Portland, OR, USA.; Departments of Behavioral Neuroscience and Pathology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Witt+SN%22">Witt SN</searchLink>; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.; Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Larsen+DH%22">Larsen DH</searchLink>; Danish Cancer Institute, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Unni+VK%22">Unni VK</searchLink>; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA.; OHSU Parkinson Center, Oregon Health and Science University, Portland, OR, USA.
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