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Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation.

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Title: Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation.
Authors: Ravussin E; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Sanchez-Delgado G; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Department of Medicine, Division of Endocrinology, Center de Recherche du Center Hospitalier de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada; Sport and Health University Research Institute and Institute of Nutrition and Food Technology 'José Mataix', University of Granada, Granada, Spain; Instituto de Investigación Biosanitaria Ibs. Granada, Granada, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Martin CK; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Beyl RA; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Greenway FL; Pennington Biomedical Research Center, Baton Rouge, LA, USA., O'Farrell LS; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Roell WC; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Qian HR; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Li J; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Nishiyama H; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Haupt A; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Pratt EJ; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Urva S; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Milicevic Z; Eli Lilly and Company, Vienna, Austria., Coskun T; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA. Electronic address: coskun_tamer@lilly.com.
Source: Cell metabolism [Cell Metab] 2025 May 06; Vol. 37 (5), pp. 1060-1074.e4. Date of Electronic Publication: 2025 Apr 08.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation.
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  Data: <searchLink fieldCode="AU" term="%22Ravussin+E%22">Ravussin E</searchLink>; Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Sanchez-Delgado+G%22">Sanchez-Delgado G</searchLink>; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Department of Medicine, Division of Endocrinology, Center de Recherche du Center Hospitalier de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada; Sport and Health University Research Institute and Institute of Nutrition and Food Technology 'José Mataix', University of Granada, Granada, Spain; Instituto de Investigación Biosanitaria Ibs. Granada, Granada, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martin+CK%22">Martin CK</searchLink>; Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Beyl+RA%22">Beyl RA</searchLink>; Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Greenway+FL%22">Greenway FL</searchLink>; Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22O'Farrell+LS%22">O'Farrell LS</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Roell+WC%22">Roell WC</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Qian+HR%22">Qian HR</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Nishiyama+H%22">Nishiyama H</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Haupt+A%22">Haupt A</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Pratt+EJ%22">Pratt EJ</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Urva+S%22">Urva S</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Milicevic+Z%22">Milicevic Z</searchLink>; Eli Lilly and Company, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Coskun+T%22">Coskun T</searchLink>; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA. Electronic address: coskun_tamer@lilly.com.
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  Data: <searchLink fieldCode="JN" term="%22101233170%22">Cell metabolism</searchLink> [Cell Metab] 2025 May 06; Vol. 37 (5), pp. 1060-1074.e4. <i>Date of Electronic Publication: </i>2025 Apr 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101233170 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-7420 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215504131%22">15504131 </searchLink><i>NLM ISO Abbreviation: </i>Cell Metab <i>Subsets: </i>MEDLINE
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              Text: 2025 May 06
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