Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation. - Ravussin E; Sanchez-Delgado G; Martin CK; Beyl RA; Greenway FL; O'Farrell LS; Roell WC; Qian HR; Li J; Nishiyama H; Haupt A; Pratt EJ; et al. (Cell metabolism, 2025)