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Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient associations and regulators.

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Title: Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient associations and regulators.
Authors: Stea ED; Unit of Nephrology, Dialysis and Transplantation, Fondazione I.R.C.C.S. Policlinico San Matteo, 27100 Pavia, Italy. Electronic address: emmadiletta.stea@gmail.com., Pugliano M; Immunohematology and Transfusion Medicine Unit, Department of Transfusion Medicine and Hematology, Milano Nord Grande Ospedale Metropolitano Niguarda, Milan, Italy. Electronic address: mariateresa.pugliano@ospedaleniguarda.it., Gualtierotti R; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, S.C. Medicina - Emostasi e Trombosi, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via Pace 9, 20122, Milan, Italy. Electronic address: roberta.gualtierotti@unimi.it., Mazzucato M; Coordinamento Malattie Rare Regione Veneto, Padua University Hospital, Via Giustiniani 2, Padua 35128, Italy. Electronic address: monica.mazzucato@regione.veneto.it., Santangelo L; Pediatric Nephrology and Dialysis Unit, Giovanni XXIII Pediatric Hospital, via Giovanni Amendola 207, Bari 70125, Italy. Electronic address: luisa.santangelo@hotmail.it., Annicchiarico G; Coordinamento Malattie Rare Regione Puglia - Strategic Regional Agency for Health and Social Affairs (AReSS Puglia), Lungomare Nazario Sauro 33, 70121 Bari, Italy. Electronic address: annicchiarico.giuseppina@gmail.com., Berardelli A; Department of Human Neuroscience, Viale Università 30, Roma, Italia; NEUROMED IRCCS, Pozzilli (IS), via Atinense 18, Pozzilli, Isernia 86077, Italia.. Electronic address: alfredo.berardelli@uniroma1.it., Bianchi S; Società Italiana di Nefrologia (SIN Nefrologia), via dell'Università 11, 00185 Rome, Italy. Electronic address: stefanobianchi0205@gmail.com., Bogliolo L; Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, Viale Camillo Golgi 19, 27100 Pavia, Italy. Electronic address: l.bogliolo@smatteo.pv.it., Chiandotto P; Progetto Alice Associazione per la lotta alla SEU, Via Gaetano Donizetti, 24/C, 20866, Carnate, Italy. Electronic address: presidente@progettoalice-seu.org., Cirino G; Department of Pharmacy, University Federico II, Via Domenico Montesano 49, 80131, Naples, Italy. Electronic address: giuseppe.cirino@unina.it., De Iaco F; Medicina Emergenza Urgenza 1, Ospedale Maria Vittoria, Via Cibrario 72, ASL Città di Torino, Turin, Italy. Electronic address: dr.fabio.deiaco@gmail.com., De Rosa S; Centre for Medical Sciences, University of Trento, Via S. Maria Maddalena 1, 38122, Trento, Italy. Electronic address: silvia.derosa@unitn.it., Dentali F; Department of Medicine and Surgery, Insubria University, Via Ravasi, 2, 21100, Varese, Italy. Electronic address: francesco.dentali@asst-settelaghi.it., Facchin P; Coordinamento Malattie Rare Regione Veneto, Padua University Hospital, Via Giustiniani 2, Padua 35128, Italy. Electronic address: paola.facchin@unipd.it., Favalli EG; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via Festa del Perdono 7, 20122, Milan, Italy; Department of Rheumatology and Medical Sciences, ASST Gaetano Pini-CTO, Piazza Cardinal Ferrari 1, 20122, Milan, Italy. Electronic address: ennio.favalli@unimi.it., Fiorin F; Transfusion Medicine Department ULSS 8 Berica, V. le Rodolfi 31, 31100, Vicenza, Italy. Electronic address: francesco.fiorin@simti.it., Giarratano A; Department of Precision Medicine in Medical, Surgical and Critical Care (Me. Pre. C. C.), University of Palermo, via Liborio Giuffrè 5, 90127, Palermo, Italy; Department of Anesthesia, Analgesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Palermo, Italy. Electronic address: antonino.giarratano@siaarti.it., Laterza C; Coordinamento Malattie Rare Regione Puglia - Strategic Regional Agency for Health and Social Affairs (AReSS Puglia), Lungomare Nazario Sauro 33, 70121 Bari, Italy. Electronic address: claulate@gmail.com., Macrì F; Federazione delle Società Medico-Scientifiche Italiane (FISM), via Luigi Casanova 1, 20125, Milan, Italy. Electronic address: profmacri@gmail.com., Mancuso M; Department of Clinical and Experimental Medicine Neurological Institute, University of Pisa, 56100, Pisa, Italy. Electronic address: michelangelo.mancuso@unipi.it., Padovani A; Unità di Neurologia, Dipartimento Scienze Cliniche e Sperimentali, Università degli Studi di Brescia, 25123, Brescia, Italy. Electronic address: alessandro.padovani@unibs.it., Pasini A; Pediatric Nephrology and Dialysis Unit, IRCCS AOU of Bologna, via Massarenti 11, 40138, Bologna, Italy. Electronic address: andrea.pasini@aosp.bo.it., Scopinaro AM; UNIAMO Federazione Italiana Malattie Rare, via Nomentana 133, 00161, Rome, Italy. Electronic address: presidente@uniamo.org., Sebastiani GD; Rheumatology Department, AO San Camillo-Forlanini, Cir.ne Gianicolense 87, 00152, Rome, Italy. Electronic address: gsebastiani@scamilloforlanini.rm.it., Sesti G; Department of Clinical and Molecular Medicine, Sapienza University of Rome, via Giorgio Nicola Papanicolau, 00189, Rome, Italy. Electronic address: giorgio.sesti@uniroma1.it., Susi B; DEA, Ospedale S. Paolo, Largo donatori di sangue 1, Civitavecchia, 00053 Rome, Italy. Electronic address: beniaminosusi@gmail.com., Torsello A; School of Medicine and Surgery, University Milano-Bicocca, via Cadore 48, Monza 20900, Italy. Electronic address: antonio.torsello@unimib.it., Vezzoni C; Progetto Alice Associazione per la lotta alla SEU, Via Gaetano Donizetti, 24/C, 20866, Carnate, Italy. Electronic address: cinzia@progettoalice-seu.org., Zanlari L; Department of Internal Medicine, Fiorenzuola d'Arda Hospital, AUSL Piacenza, via Roma 29, 29017, Fiorenzuola (PC), Italy. Electronic address: zallo.luca@gmail.com., Gesualdo L; Federazione delle Società Medico-Scientifiche Italiane (FISM), via Luigi Casanova 1, 20125, Milan, Italy. Electronic address: presidente@fism.it., De Luca A; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, Via E. Orabona 4 - Campus, 70125, Bari, Italy. Electronic address: annamaria.deluca@uniba.it.
Source: Pharmacological research [Pharmacol Res] 2025 Jun; Vol. 216, pp. 107714. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article; Review; Consensus Statement
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
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  Data: Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient associations and regulators.
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  Data: <searchLink fieldCode="AU" term="%22Stea+ED%22">Stea ED</searchLink>; Unit of Nephrology, Dialysis and Transplantation, Fondazione I.R.C.C.S. Policlinico San Matteo, 27100 Pavia, Italy. Electronic address: emmadiletta.stea@gmail.com.<br /><searchLink fieldCode="AU" term="%22Pugliano+M%22">Pugliano M</searchLink>; Immunohematology and Transfusion Medicine Unit, Department of Transfusion Medicine and Hematology, Milano Nord Grande Ospedale Metropolitano Niguarda, Milan, Italy. Electronic address: mariateresa.pugliano@ospedaleniguarda.it.<br /><searchLink fieldCode="AU" term="%22Gualtierotti+R%22">Gualtierotti R</searchLink>; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, S.C. Medicina - Emostasi e Trombosi, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via Pace 9, 20122, Milan, Italy. Electronic address: roberta.gualtierotti@unimi.it.<br /><searchLink fieldCode="AU" term="%22Mazzucato+M%22">Mazzucato M</searchLink>; Coordinamento Malattie Rare Regione Veneto, Padua University Hospital, Via Giustiniani 2, Padua 35128, Italy. Electronic address: monica.mazzucato@regione.veneto.it.<br /><searchLink fieldCode="AU" term="%22Santangelo+L%22">Santangelo L</searchLink>; Pediatric Nephrology and Dialysis Unit, Giovanni XXIII Pediatric Hospital, via Giovanni Amendola 207, Bari 70125, Italy. Electronic address: luisa.santangelo@hotmail.it.<br /><searchLink fieldCode="AU" term="%22Annicchiarico+G%22">Annicchiarico G</searchLink>; Coordinamento Malattie Rare Regione Puglia - Strategic Regional Agency for Health and Social Affairs (AReSS Puglia), Lungomare Nazario Sauro 33, 70121 Bari, Italy. Electronic address: annicchiarico.giuseppina@gmail.com.<br /><searchLink fieldCode="AU" term="%22Berardelli+A%22">Berardelli A</searchLink>; Department of Human Neuroscience, Viale Università 30, Roma, Italia; NEUROMED IRCCS, Pozzilli (IS), via Atinense 18, Pozzilli, Isernia 86077, Italia.. Electronic address: alfredo.berardelli@uniroma1.it.<br /><searchLink fieldCode="AU" term="%22Bianchi+S%22">Bianchi S</searchLink>; Società Italiana di Nefrologia (SIN Nefrologia), via dell'Università 11, 00185 Rome, Italy. Electronic address: stefanobianchi0205@gmail.com.<br /><searchLink fieldCode="AU" term="%22Bogliolo+L%22">Bogliolo L</searchLink>; Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, Viale Camillo Golgi 19, 27100 Pavia, Italy. Electronic address: l.bogliolo@smatteo.pv.it.<br /><searchLink fieldCode="AU" term="%22Chiandotto+P%22">Chiandotto P</searchLink>; Progetto Alice Associazione per la lotta alla SEU, Via Gaetano Donizetti, 24/C, 20866, Carnate, Italy. Electronic address: presidente@progettoalice-seu.org.<br /><searchLink fieldCode="AU" term="%22Cirino+G%22">Cirino G</searchLink>; Department of Pharmacy, University Federico II, Via Domenico Montesano 49, 80131, Naples, Italy. Electronic address: giuseppe.cirino@unina.it.<br /><searchLink fieldCode="AU" term="%22De+Iaco+F%22">De Iaco F</searchLink>; Medicina Emergenza Urgenza 1, Ospedale Maria Vittoria, Via Cibrario 72, ASL Città di Torino, Turin, Italy. Electronic address: dr.fabio.deiaco@gmail.com.<br /><searchLink fieldCode="AU" term="%22De+Rosa+S%22">De Rosa S</searchLink>; Centre for Medical Sciences, University of Trento, Via S. Maria Maddalena 1, 38122, Trento, Italy. Electronic address: silvia.derosa@unitn.it.<br /><searchLink fieldCode="AU" term="%22Dentali+F%22">Dentali F</searchLink>; Department of Medicine and Surgery, Insubria University, Via Ravasi, 2, 21100, Varese, Italy. Electronic address: francesco.dentali@asst-settelaghi.it.<br /><searchLink fieldCode="AU" term="%22Facchin+P%22">Facchin P</searchLink>; Coordinamento Malattie Rare Regione Veneto, Padua University Hospital, Via Giustiniani 2, Padua 35128, Italy. Electronic address: paola.facchin@unipd.it.<br /><searchLink fieldCode="AU" term="%22Favalli+EG%22">Favalli EG</searchLink>; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via Festa del Perdono 7, 20122, Milan, Italy; Department of Rheumatology and Medical Sciences, ASST Gaetano Pini-CTO, Piazza Cardinal Ferrari 1, 20122, Milan, Italy. Electronic address: ennio.favalli@unimi.it.<br /><searchLink fieldCode="AU" term="%22Fiorin+F%22">Fiorin F</searchLink>; Transfusion Medicine Department ULSS 8 Berica, V. le Rodolfi 31, 31100, Vicenza, Italy. Electronic address: francesco.fiorin@simti.it.<br /><searchLink fieldCode="AU" term="%22Giarratano+A%22">Giarratano A</searchLink>; Department of Precision Medicine in Medical, Surgical and Critical Care (Me. Pre. C. C.), University of Palermo, via Liborio Giuffrè 5, 90127, Palermo, Italy; Department of Anesthesia, Analgesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Palermo, Italy. Electronic address: antonino.giarratano@siaarti.it.<br /><searchLink fieldCode="AU" term="%22Laterza+C%22">Laterza C</searchLink>; Coordinamento Malattie Rare Regione Puglia - Strategic Regional Agency for Health and Social Affairs (AReSS Puglia), Lungomare Nazario Sauro 33, 70121 Bari, Italy. Electronic address: claulate@gmail.com.<br /><searchLink fieldCode="AU" term="%22Macrì+F%22">Macrì F</searchLink>; Federazione delle Società Medico-Scientifiche Italiane (FISM), via Luigi Casanova 1, 20125, Milan, Italy. Electronic address: profmacri@gmail.com.<br /><searchLink fieldCode="AU" term="%22Mancuso+M%22">Mancuso M</searchLink>; Department of Clinical and Experimental Medicine Neurological Institute, University of Pisa, 56100, Pisa, Italy. Electronic address: michelangelo.mancuso@unipi.it.<br /><searchLink fieldCode="AU" term="%22Padovani+A%22">Padovani A</searchLink>; Unità di Neurologia, Dipartimento Scienze Cliniche e Sperimentali, Università degli Studi di Brescia, 25123, Brescia, Italy. Electronic address: alessandro.padovani@unibs.it.<br /><searchLink fieldCode="AU" term="%22Pasini+A%22">Pasini A</searchLink>; Pediatric Nephrology and Dialysis Unit, IRCCS AOU of Bologna, via Massarenti 11, 40138, Bologna, Italy. Electronic address: andrea.pasini@aosp.bo.it.<br /><searchLink fieldCode="AU" term="%22Scopinaro+AM%22">Scopinaro AM</searchLink>; UNIAMO Federazione Italiana Malattie Rare, via Nomentana 133, 00161, Rome, Italy. Electronic address: presidente@uniamo.org.<br /><searchLink fieldCode="AU" term="%22Sebastiani+GD%22">Sebastiani GD</searchLink>; Rheumatology Department, AO San Camillo-Forlanini, Cir.ne Gianicolense 87, 00152, Rome, Italy. Electronic address: gsebastiani@scamilloforlanini.rm.it.<br /><searchLink fieldCode="AU" term="%22Sesti+G%22">Sesti G</searchLink>; Department of Clinical and Molecular Medicine, Sapienza University of Rome, via Giorgio Nicola Papanicolau, 00189, Rome, Italy. Electronic address: giorgio.sesti@uniroma1.it.<br /><searchLink fieldCode="AU" term="%22Susi+B%22">Susi B</searchLink>; DEA, Ospedale S. Paolo, Largo donatori di sangue 1, Civitavecchia, 00053 Rome, Italy. Electronic address: beniaminosusi@gmail.com.<br /><searchLink fieldCode="AU" term="%22Torsello+A%22">Torsello A</searchLink>; School of Medicine and Surgery, University Milano-Bicocca, via Cadore 48, Monza 20900, Italy. Electronic address: antonio.torsello@unimib.it.<br /><searchLink fieldCode="AU" term="%22Vezzoni+C%22">Vezzoni C</searchLink>; Progetto Alice Associazione per la lotta alla SEU, Via Gaetano Donizetti, 24/C, 20866, Carnate, Italy. Electronic address: cinzia@progettoalice-seu.org.<br /><searchLink fieldCode="AU" term="%22Zanlari+L%22">Zanlari L</searchLink>; Department of Internal Medicine, Fiorenzuola d'Arda Hospital, AUSL Piacenza, via Roma 29, 29017, Fiorenzuola (PC), Italy. Electronic address: zallo.luca@gmail.com.<br /><searchLink fieldCode="AU" term="%22Gesualdo+L%22">Gesualdo L</searchLink>; Federazione delle Società Medico-Scientifiche Italiane (FISM), via Luigi Casanova 1, 20125, Milan, Italy. Electronic address: presidente@fism.it.<br /><searchLink fieldCode="AU" term="%22De+Luca+A%22">De Luca A</searchLink>; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, Via E. Orabona 4 - Campus, 70125, Bari, Italy. Electronic address: annamaria.deluca@uniba.it.
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