Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism.

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Title: Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism.
Authors: Steiner KK; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Young AC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Patterson AR; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Sugiura A; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Watson MJ; Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Preston SEJ; Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Zhelonkin A; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Jennings EQ; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Chi C; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Heintzman DR; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Pahnke AP; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Toudji YT; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Hatem Z; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Madden MZ; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Arner EN; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Sewell AE; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Blount AK; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Okparaugo R; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Fallman E; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Krystofiak ES; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, United States., Sheldon RD; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, United States., Gibson-Corley KN; Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Voss K; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Nowinski SM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, United States., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, United States.; Metabolism and Nutrition Program, Van Andel Institute, Grand Rapids, MI, United States., Mogilenko DA; Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, United States., Rathmell JC; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, United States.
Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 May 01; Vol. 214 (5), pp. 958-976.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
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  Data: Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism.
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Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Zhelonkin+A%22">Zhelonkin A</searchLink>; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Jennings+EQ%22">Jennings EQ</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Chi+C%22">Chi C</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Heintzman+DR%22">Heintzman DR</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Pahnke+AP%22">Pahnke AP</searchLink>; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Toudji+YT%22">Toudji YT</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Hatem+Z%22">Hatem Z</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Madden+MZ%22">Madden MZ</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Arner+EN%22">Arner EN</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Sewell+AE%22">Sewell AE</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Blount+AK%22">Blount AK</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Okparaugo+R%22">Okparaugo R</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Fallman+E%22">Fallman E</searchLink>; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Krystofiak+ES%22">Krystofiak ES</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Sheldon+RD%22">Sheldon RD</searchLink>; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, United States.<br /><searchLink fieldCode="AU" term="%22Gibson-Corley+KN%22">Gibson-Corley KN</searchLink>; Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Voss+K%22">Voss K</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Nowinski+SM%22">Nowinski SM</searchLink>; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, United States.<br /><searchLink fieldCode="AU" term="%22Jones+RG%22">Jones RG</searchLink>; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, United States.; Metabolism and Nutrition Program, Van Andel Institute, Grand Rapids, MI, United States.<br /><searchLink fieldCode="AU" term="%22Mogilenko+DA%22">Mogilenko DA</searchLink>; Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Rathmell+JC%22">Rathmell JC</searchLink>; Division of Molecular Pathology, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985117R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-6606 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221767%22">00221767 </searchLink><i>NLM ISO Abbreviation: </i>J Immunol <i>Subsets: </i>MEDLINE
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