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Rational design of alternative treatment options for radioresistant rectal cancer using patient-derived organoids.

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Title: Rational design of alternative treatment options for radioresistant rectal cancer using patient-derived organoids.
Authors: Andel D; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Nouwens AJ; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Klaassen S; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Laoukili J; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Viergever B; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Verheem A; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Intven MPW; Department of Radiation Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Zandvliet M; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Hagendoorn J; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Borel Rinkes IHM; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. I.H.M.BorelRinkes@umcutrecht.nl.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. I.H.M.BorelRinkes@umcutrecht.nl., Kranenburg O; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.
Source: British journal of cancer [Br J Cancer] 2025 Jun; Vol. 132 (10), pp. 973-981. Date of Electronic Publication: 2025 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Andel+D%22">Andel D</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nouwens+AJ%22">Nouwens AJ</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Klaassen+S%22">Klaassen S</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Laoukili+J%22">Laoukili J</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Viergever+B%22">Viergever B</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verheem+A%22">Verheem A</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Intven+MPW%22">Intven MPW</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zandvliet+M%22">Zandvliet M</searchLink>; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hagendoorn+J%22">Hagendoorn J</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Borel+Rinkes+IHM%22">Borel Rinkes IHM</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. I.H.M.BorelRinkes@umcutrecht.nl.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. I.H.M.BorelRinkes@umcutrecht.nl.<br /><searchLink fieldCode="AU" term="%22Kranenburg+O%22">Kranenburg O</searchLink>; Department of Surgical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.; Laboratory for Translational Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, The Netherlands. O.Kranenburg@umcutrecht.nl.
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  Data: <searchLink fieldCode="JN" term="%220370635%22">British journal of cancer</searchLink> [Br J Cancer] 2025 Jun; Vol. 132 (10), pp. 973-981. <i>Date of Electronic Publication: </i>2025 Apr 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+on+behalf+of+Cancer+Research+UK%22">Nature Publishing Group on behalf of Cancer Research UK </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0370635 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-1827 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200070920%22">00070920 </searchLink><i>NLM ISO Abbreviation: </i>Br J Cancer <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun
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