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Reprogramming site-specific retrotransposon activity to new DNA sites.

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Title: Reprogramming site-specific retrotransposon activity to new DNA sites.
Authors: Fell CW; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Villiger L; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Lim J; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Hiraizumi M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Tagliaferri D; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Yarnall MTN; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Lee A; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Jiang K; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Kayabolen A; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Krajeski RN; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Schmitt-Ulms C; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Ramani H; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Yousef SM; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Roberts N; Integrated DNA Technologies, Coralville, Iowa, USA., Vakulskas CA; Integrated DNA Technologies, Coralville, Iowa, USA., Nishimasu H; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.; Structural Biology Division Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Inamori Research Institute for Science, Kyoto, Japan., Abudayyeh OO; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. omar@abudayyeh.science.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA. omar@abudayyeh.science.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. omar@abudayyeh.science.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA. omar@abudayyeh.science., Gootenberg JS; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jgootenb@bidmc.harvard.edu.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA. jgootenb@bidmc.harvard.edu.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. jgootenb@bidmc.harvard.edu.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA. jgootenb@bidmc.harvard.edu.
Source: Nature [Nature] 2025 Jun; Vol. 642 (8069), pp. 1080-1089. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fell+CW%22">Fell CW</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Villiger+L%22">Villiger L</searchLink>; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lim+J%22">Lim J</searchLink>; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hiraizumi+M%22">Hiraizumi M</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tagliaferri+D%22">Tagliaferri D</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yarnall+MTN%22">Yarnall MTN</searchLink>; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+A%22">Lee A</searchLink>; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+K%22">Jiang K</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kayabolen+A%22">Kayabolen A</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Krajeski+RN%22">Krajeski RN</searchLink>; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schmitt-Ulms+C%22">Schmitt-Ulms C</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ramani+H%22">Ramani H</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yousef+SM%22">Yousef SM</searchLink>; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+N%22">Roberts N</searchLink>; Integrated DNA Technologies, Coralville, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Vakulskas+CA%22">Vakulskas CA</searchLink>; Integrated DNA Technologies, Coralville, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Nishimasu+H%22">Nishimasu H</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.; Structural Biology Division Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Inamori Research Institute for Science, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Abudayyeh+OO%22">Abudayyeh OO</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. omar@abudayyeh.science.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA. omar@abudayyeh.science.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. omar@abudayyeh.science.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA. omar@abudayyeh.science.<br /><searchLink fieldCode="AU" term="%22Gootenberg+JS%22">Gootenberg JS</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jgootenb@bidmc.harvard.edu.; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA. jgootenb@bidmc.harvard.edu.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. jgootenb@bidmc.harvard.edu.; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA. jgootenb@bidmc.harvard.edu.
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