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Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles.

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Title: Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles.
Authors: Østergaard ME; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Carrer M; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Anderson BA; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Afetian M; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Bakooshli MA; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Santos JA; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Klein SK; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Capitanio J; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Freestone GC; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Tanowitz M; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Galindo-Murillo R; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Gaus HJ; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Dwyer CA; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Jackson M; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Jafar-Nejad P; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Rigo F; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Seth PP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States., Gaynor KU; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Stanway SJ; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Urbonas L; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., St Denis MA; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Pellegrino S; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Bezerra GA; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Rigby M; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Gowans E; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Van Rietschoten K; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Beswick P; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Chen L; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Skynner MJ; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom., Swayze EE; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Apr 10; Vol. 53 (7).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles.
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  Data: <searchLink fieldCode="AU" term="%22Østergaard+ME%22">Østergaard ME</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Carrer+M%22">Carrer M</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Anderson+BA%22">Anderson BA</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Afetian+M%22">Afetian M</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Bakooshli+MA%22">Bakooshli MA</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Santos+JA%22">Santos JA</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Klein+SK%22">Klein SK</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Capitanio+J%22">Capitanio J</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Freestone+GC%22">Freestone GC</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Tanowitz+M%22">Tanowitz M</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Galindo-Murillo+R%22">Galindo-Murillo R</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Gaus+HJ%22">Gaus HJ</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Dwyer+CA%22">Dwyer CA</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Jackson+M%22">Jackson M</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Jafar-Nejad+P%22">Jafar-Nejad P</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Rigo+F%22">Rigo F</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Seth+PP%22">Seth PP</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Gaynor+KU%22">Gaynor KU</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stanway+SJ%22">Stanway SJ</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Urbonas+L%22">Urbonas L</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22St+Denis+MA%22">St Denis MA</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pellegrino+S%22">Pellegrino S</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bezerra+GA%22">Bezerra GA</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rigby+M%22">Rigby M</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gowans+E%22">Gowans E</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Van+Rietschoten+K%22">Van Rietschoten K</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Beswick+P%22">Beswick P</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Skynner+MJ%22">Skynner MJ</searchLink>; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge CB21 6GS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Swayze+EE%22">Swayze EE</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.
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