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Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma.

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Title: Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma.
Authors: Smith SJ; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California., Meng F; Department of Surgery, City of Hope Cancer Center, Duarte, California., Lingeman RG; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California., Li CM; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California., Li M; Department of Cancer Genetics and Epigenetics, City of Hope Cancer Center, Duarte, California., Boneh G; Department of Surgery, City of Hope Cancer Center, Duarte, California., Seppälä TT; Division of Hepatobiliary and Pancreatic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Gastroenterology and Alimentary Tract Surgery and TAYS Cancer Centre, Tampere University Hospital, Tampere, Finland., Phan T; Department of Surgery, City of Hope Cancer Center, Duarte, California., Li H; Integrative Genomic Core, Beckman Research Institute of City of Hope, Duarte, California., Burkhart RA; Division of Hepatobiliary and Pancreatic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Parekh V; Department of Pathology, City of Hope Cancer Center, Duarte, California., Rahmanuddin S; Department of Radiology, City of Hope Cancer Center, Duarte, California., Melstrom LG; Department of Surgery, City of Hope Cancer Center, Duarte, California., Hickey RJ; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California., Chung V; Department of Medical Oncology, City of Hope Cancer Center, Duarte, California., Liu Y; Department of Cancer Genetics and Epigenetics, City of Hope Cancer Center, Duarte, California., Malkas LH; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California., Raoof M; Department of Surgery, City of Hope Cancer Center, Duarte, California; Department of Cancer Genetics and Epigenetics, City of Hope Cancer Center, Duarte, California. Electronic address: mraoof@coh.org.
Source: Gastroenterology [Gastroenterology] 2025 Sep; Vol. 169 (4), pp. 600-614.e11. Date of Electronic Publication: 2025 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
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  Data: Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Smith+SJ%22">Smith SJ</searchLink>; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Meng+F%22">Meng F</searchLink>; Department of Surgery, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Lingeman+RG%22">Lingeman RG</searchLink>; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Li+CM%22">Li CM</searchLink>; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Cancer Genetics and Epigenetics, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Boneh+G%22">Boneh G</searchLink>; Department of Surgery, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Seppälä+TT%22">Seppälä TT</searchLink>; Division of Hepatobiliary and Pancreatic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Gastroenterology and Alimentary Tract Surgery and TAYS Cancer Centre, Tampere University Hospital, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Phan+T%22">Phan T</searchLink>; Department of Surgery, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Integrative Genomic Core, Beckman Research Institute of City of Hope, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Burkhart+RA%22">Burkhart RA</searchLink>; Division of Hepatobiliary and Pancreatic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Parekh+V%22">Parekh V</searchLink>; Department of Pathology, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Rahmanuddin+S%22">Rahmanuddin S</searchLink>; Department of Radiology, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Melstrom+LG%22">Melstrom LG</searchLink>; Department of Surgery, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Hickey+RJ%22">Hickey RJ</searchLink>; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Chung+V%22">Chung V</searchLink>; Department of Medical Oncology, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Cancer Genetics and Epigenetics, City of Hope Cancer Center, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Malkas+LH%22">Malkas LH</searchLink>; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Raoof+M%22">Raoof M</searchLink>; Department of Surgery, City of Hope Cancer Center, Duarte, California; Department of Cancer Genetics and Epigenetics, City of Hope Cancer Center, Duarte, California. Electronic address: mraoof@coh.org.
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