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Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats.

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Title: Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats.
Authors: Scripcariu DV; Department of Surgery, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Caratașu CC; Advanced Center for Research and Development in Experimental Medicine 'Prof. Ostin C. Mungiu' (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Ciorpac M; Advanced Center for Research and Development in Experimental Medicine 'Prof. Ostin C. Mungiu' (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Alexa-Stratulat T; Department of Medical Oncology and Radiotherapy, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Szilagyi A; Advanced Center for Research and Development in Experimental Medicine 'Prof. Ostin C. Mungiu' (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Buga CR; Stereotactic Radiosurgery Laboratory, Clinical Emergency Hospital 'Prof. Dr. Nicolae Oblu', Iasi, Romania., Dobrovăț BI; Department of Medical Oncology and Radiotherapy, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.; Stereotactic Radiosurgery Laboratory, Clinical Emergency Hospital 'Prof. Dr. Nicolae Oblu', Iasi, Romania., Eva L; Stereotactic Radiosurgery Laboratory, Clinical Emergency Hospital 'Prof. Dr. Nicolae Oblu', Iasi, Romania., Timofte AD; Department of Morphofunctional Sciences 1, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Lozneanu L; Department of Morphofunctional Sciences 1, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Căruntu ID; Department of Morphofunctional Sciences 1, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Iliescu R; Advanced Center for Research and Development in Experimental Medicine 'Prof. Ostin C. Mungiu' (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Tamba BI; Advanced Center for Research and Development in Experimental Medicine 'Prof. Ostin C. Mungiu' (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.
Source: Frontiers in pharmacology [Front Pharmacol] 2025 Mar 27; Vol. 16, pp. 1441011. Date of Electronic Publication: 2025 Mar 27 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1663-9812
DOI:10.3389/fphar.2025.1441011