Nano-carrier, design, synthesis, in silico ADMET, anti-proliferative assessments and docking of [1,2,4]triazolo[4,3-a]quinoxalines as Topo-II inhibitors and DNA intercalators.
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| Title: | Nano-carrier, design, synthesis, in silico ADMET, anti-proliferative assessments and docking of [1,2,4]triazolo[4,3-a]quinoxalines as Topo-II inhibitors and DNA intercalators. |
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| Authors: | Aljohani AKB; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, 42353, Medina, Saudi Arabia., Almadani SA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, 42353, Medina, Saudi Arabia., Alsulaimany M; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, 42353, Medina, Saudi Arabia., Aljuhani N; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, 42353, Medina, Saudi Arabia., Samman WA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, 42353, Medina, Saudi Arabia., Al-Shareef AH; Department of Chemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia., Alghamdi R; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, 42353, Medina, Saudi Arabia., Tayeb SM; Department of Pharmaceutical Science, College of Pharmacy, Umm Al-Qura University, 24381, Makkah, Saudi Arabia., Alharbi HY; Department of Chemistry, Faculty of Science, Taibah University, Yanbu, Saudi Arabia., Aljohani MS; Department of Chemistry, Faculty of Science, Taibah University, Yanbu, Saudi Arabia., El-Adl K; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt. eladlkhaled74@azhar.edu.eg.; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt. eladlkhaled74@azhar.edu.eg., Salem M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University-Arish Branch, Arish, Egypt. |
| Source: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Sep; Vol. 398 (9), pp. 12727-12743. Date of Electronic Publication: 2025 Apr 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-1912 |
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| DOI: | 10.1007/s00210-025-04052-8 |
