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Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects.

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Title: Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects.
Authors: Capello M; Genmab BV, Utrecht, Netherlands., Sette A; Genmab BV, Utrecht, Netherlands., Plantinga T; Genmab BV, Utrecht, Netherlands., Thalhauser CJ; Genmab US, Plainsboro, New Jersey, USA., Spires VM; Genmab US, Plainsboro, New Jersey, USA., Nürmberger KB; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Blum JM; Genmab US, Plainsboro, New Jersey, USA., Higgs BW; Genmab US, Plainsboro, New Jersey, USA., Garrido Castro P; Genmab BV, Utrecht, Netherlands., Yu C; Genmab US, Plainsboro, New Jersey, USA., Costa Sa C; Genmab US, Plainsboro, New Jersey, USA., Fellermeier-Kopf S; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Burm SM; Genmab BV, Utrecht, Netherlands., Strumane K; Genmab BV, Utrecht, Netherlands., Toker A; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Imle A; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., de Andrade Pereira B; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Muik A; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Ahmadi T; Genmab US, Plainsboro, New Jersey, USA., Türeci Ö; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Fereshteh M; Genmab US, Plainsboro, New Jersey, USA., Sahin U; BioNTech SE, Mainz, Rheinland-Pfalz, Germany., Jure-Kunkel M; Genmab US, Plainsboro, New Jersey, USA npe@genmab.com mjk@genmab.com., Pencheva N; Genmab BV, Utrecht, Netherlands npe@genmab.com mjk@genmab.com.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Apr 10; Vol. 13 (4). Date of Electronic Publication: 2025 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects.
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  Data: <searchLink fieldCode="AU" term="%22Capello+M%22">Capello M</searchLink>; Genmab BV, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sette+A%22">Sette A</searchLink>; Genmab BV, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Plantinga+T%22">Plantinga T</searchLink>; Genmab BV, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Thalhauser+CJ%22">Thalhauser CJ</searchLink>; Genmab US, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Spires+VM%22">Spires VM</searchLink>; Genmab US, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Nürmberger+KB%22">Nürmberger KB</searchLink>; BioNTech SE, Mainz, Rheinland-Pfalz, Germany.<br /><searchLink fieldCode="AU" term="%22Blum+JM%22">Blum JM</searchLink>; Genmab US, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Higgs+BW%22">Higgs BW</searchLink>; Genmab US, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Garrido+Castro+P%22">Garrido Castro P</searchLink>; Genmab BV, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Genmab US, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Costa+Sa+C%22">Costa Sa C</searchLink>; Genmab US, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Fellermeier-Kopf+S%22">Fellermeier-Kopf S</searchLink>; BioNTech SE, Mainz, Rheinland-Pfalz, Germany.<br /><searchLink fieldCode="AU" term="%22Burm+SM%22">Burm SM</searchLink>; Genmab BV, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Strumane+K%22">Strumane K</searchLink>; Genmab BV, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Toker+A%22">Toker A</searchLink>; BioNTech SE, Mainz, Rheinland-Pfalz, Germany.<br /><searchLink fieldCode="AU" term="%22Imle+A%22">Imle A</searchLink>; BioNTech SE, Mainz, Rheinland-Pfalz, Germany.<br /><searchLink fieldCode="AU" term="%22de+Andrade+Pereira+B%22">de Andrade Pereira B</searchLink>; BioNTech SE, Mainz, Rheinland-Pfalz, Germany.<br /><searchLink fieldCode="AU" term="%22Muik+A%22">Muik A</searchLink>; BioNTech SE, Mainz, Rheinland-Pfalz, Germany.<br /><searchLink fieldCode="AU" term="%22Ahmadi+T%22">Ahmadi T</searchLink>; Genmab US, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Türeci+Ö%22">Türeci Ö</searchLink>; BioNTech SE, Mainz, Rheinland-Pfalz, Germany.<br /><searchLink fieldCode="AU" term="%22Fereshteh+M%22">Fereshteh M</searchLink>; Genmab US, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Sahin+U%22">Sahin U</searchLink>; BioNTech SE, Mainz, Rheinland-Pfalz, Germany.<br /><searchLink fieldCode="AU" term="%22Jure-Kunkel+M%22">Jure-Kunkel M</searchLink>; Genmab US, Plainsboro, New Jersey, USA npe@genmab.com mjk@genmab.com.<br /><searchLink fieldCode="AU" term="%22Pencheva+N%22">Pencheva N</searchLink>; Genmab BV, Utrecht, Netherlands npe@genmab.com mjk@genmab.com.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2025 Apr 10; Vol. 13 (4). <i>Date of Electronic Publication: </i>2025 Apr 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2024-011377
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      – TitleFull: Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects.
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              Text: 2025 Apr 10
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