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IVF versus ICSI in patients without severe male factor infertility: a randomized clinical trial.

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Title: IVF versus ICSI in patients without severe male factor infertility: a randomized clinical trial.
Authors: Berntsen S; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Zedeler A; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Nøhr B; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Herlev, Herlev, Denmark., Rønn Petersen M; Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Grøndahl ML; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Herlev, Herlev, Denmark., Andersen LF; Department of Obstetrics and Gynaecology, Copenhagen University Hospital North Zealand, Hilleroed, Denmark., Løssl K; Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark., Løkkegaard E; Department of Obstetrics and Gynaecology, Copenhagen University Hospital North Zealand, Hilleroed, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark., Englund AL; Department of Obstetrics and Gynaecology, The Fertility Clinic, Zealand University Hospital Koege, Koege, Denmark., Vestergaard Gabrielsen A; Department of Obstetrics and Gynaecology, The Fertility Clinic, The Regional Hospital Horsens, Horsens, Denmark., Prætorius L; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Behrendt-Møller I; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Langhoff Thuesen L; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark., Vomstein K; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark., Petri Lauritsen M; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Ivanoska Trajcevski A; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Frøding Skipper D; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Westergaard D; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Pinborg A; Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark., Svarre Nielsen H; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., la Cour Freiesleben N; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. nina.la.cour.freiesleben@regionh.dk.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark. nina.la.cour.freiesleben@regionh.dk.
Source: Nature medicine [Nat Med] 2025 Jun; Vol. 31 (6), pp. 1939-1948. Date of Electronic Publication: 2025 Apr 11.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: IVF versus ICSI in patients without severe male factor infertility: a randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Berntsen+S%22">Berntsen S</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Zedeler+A%22">Zedeler A</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Nøhr+B%22">Nøhr B</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Herlev, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Rønn+Petersen+M%22">Rønn Petersen M</searchLink>; Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Grøndahl+ML%22">Grøndahl ML</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Herlev, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+LF%22">Andersen LF</searchLink>; Department of Obstetrics and Gynaecology, Copenhagen University Hospital North Zealand, Hilleroed, Denmark.<br /><searchLink fieldCode="AU" term="%22Løssl+K%22">Løssl K</searchLink>; Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Løkkegaard+E%22">Løkkegaard E</searchLink>; Department of Obstetrics and Gynaecology, Copenhagen University Hospital North Zealand, Hilleroed, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Englund+AL%22">Englund AL</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Zealand University Hospital Koege, Koege, Denmark.<br /><searchLink fieldCode="AU" term="%22Vestergaard+Gabrielsen+A%22">Vestergaard Gabrielsen A</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, The Regional Hospital Horsens, Horsens, Denmark.<br /><searchLink fieldCode="AU" term="%22Prætorius+L%22">Prætorius L</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Behrendt-Møller+I%22">Behrendt-Møller I</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Langhoff+Thuesen+L%22">Langhoff Thuesen L</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Vomstein+K%22">Vomstein K</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Petri+Lauritsen+M%22">Petri Lauritsen M</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Ivanoska+Trajcevski+A%22">Ivanoska Trajcevski A</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Frøding+Skipper+D%22">Frøding Skipper D</searchLink>; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Westergaard+D%22">Westergaard D</searchLink>; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Pinborg+A%22">Pinborg A</searchLink>; Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Svarre+Nielsen+H%22">Svarre Nielsen H</searchLink>; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22la+Cour+Freiesleben+N%22">la Cour Freiesleben N</searchLink>; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. nina.la.cour.freiesleben@regionh.dk.; Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark. nina.la.cour.freiesleben@regionh.dk.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2025 Jun; Vol. 31 (6), pp. 1939-1948. <i>Date of Electronic Publication: </i>2025 Apr 11.
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