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Indoxyl sulfate is associated with cognitive impairment in ESRD patients by activating the extrinsic apoptosis in the neuronal cells during differentiating process.

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Title: Indoxyl sulfate is associated with cognitive impairment in ESRD patients by activating the extrinsic apoptosis in the neuronal cells during differentiating process.
Authors: Hsieh CC; Department of Surgery, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan.; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan., Lu KC; Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; Division of Nephrology, Department of Medicine, Fu-Jen Catholic University Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan., Huang CL; Department of Medical Research, Cardinal Tien Hospital, New Taipei City, Taiwan.; Department of Physiology and Biophysics, National Defense Medical Center, Graduate Institute of Physiology, Taipei, Taiwan., Wang JJ; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University., Yeh TY; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City, Taiwan., Lin SM; Division of Radiology, Department of Medicine, Cardinal Tien Hospital, New Taipei City, Taiwan., Chung YL; Department of Medical Laboratory, Cardinal-Tien Hospital, New Taipei City, Taiwan., Hou YC; Division of Nephrology, Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, New Taipei City, Taiwan., Huang YS; Department of Biology and Anatomy, National Defense Medical Center, Taipei City 11490, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2025 Mar 10; Vol. 22 (8), pp. 1736-1749. Date of Electronic Publication: 2025 Mar 10 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: Indoxyl sulfate is associated with cognitive impairment in ESRD patients by activating the extrinsic apoptosis in the neuronal cells during differentiating process.
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  Data: <searchLink fieldCode="AU" term="%22Hsieh+CC%22">Hsieh CC</searchLink>; Department of Surgery, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan.; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+KC%22">Lu KC</searchLink>; Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; Division of Nephrology, Department of Medicine, Fu-Jen Catholic University Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CL%22">Huang CL</searchLink>; Department of Medical Research, Cardinal Tien Hospital, New Taipei City, Taiwan.; Department of Physiology and Biophysics, National Defense Medical Center, Graduate Institute of Physiology, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JJ%22">Wang JJ</searchLink>; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University.<br /><searchLink fieldCode="AU" term="%22Yeh+TY%22">Yeh TY</searchLink>; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SM%22">Lin SM</searchLink>; Division of Radiology, Department of Medicine, Cardinal Tien Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chung+YL%22">Chung YL</searchLink>; Department of Medical Laboratory, Cardinal-Tien Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hou+YC%22">Hou YC</searchLink>; Division of Nephrology, Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YS%22">Huang YS</searchLink>; Department of Biology and Anatomy, National Defense Medical Center, Taipei City 11490, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101213954%22">International journal of medical sciences</searchLink> [Int J Med Sci] 2025 Mar 10; Vol. 22 (8), pp. 1736-1749. <i>Date of Electronic Publication: </i>2025 Mar 10 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International+Publisher%22">Ivyspring International Publisher </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101213954 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1449-1907 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214491907%22">14491907 </searchLink><i>NLM ISO Abbreviation: </i>Int J Med Sci <i>Subsets: </i>MEDLINE
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        Value: 10.7150/ijms.109245
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      – Code: eng
        Text: English
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              Text: 2025 Mar 10
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